Azelnidipine - 10mM in DMSO , Voltage-gated L-type calcium channel blocker, CAS No.123524-52-7, Voltage-gated L-type calcium channel blocker

CAS: 123524-52-7 Cat. No.: A408670 Molecular Weight: 582.65 EC Number: 634-143-0

GRADE & PURITY 10mM in DMSO

Synonyms

UR-12592 | 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Azelnidipine Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker.
In vitro

Azelnidipine is a newly developed long-acting calcium channel blocker with unique pharmacological features, e.g. cardiac slowing action and high affinity to vascular tissues, which distinguishes itself from other calcium channel blockers. Azelnidipine, thus, became a new generation of calcium channel blocker that can be used for the treatment of hypertensive patients with or without potential ischemic heart diseases. Because this new calcium antagonist is highly lipid soluble, it is retained in the vascular wall after clearance from the blood and continues to elicit a hypotensive effect.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

UR-12592 | 3, 5-Pyridinedicarboxylic acid, 2-amino-1, 4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

BLOCKER

Mechanism of action

Voltage-gated L-type calcium channel blocker

Product Properties

• ALogP: 6

Names and Identifiers

• Isomeric SMILES: CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC(C)C
• WGK Germany: 3
• RTECS: US7968332
• Molecular Weight: 582.65
• Reaxy-Rn: 7420123
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7420123&ln=

References

1. Xiaofei Ma, Jing Cao, Juan Yu, Liangliang Cai.  (2022)  Evaluation of an ionic liquid chiral selector based on sulfobutylether-β-cyclodextrin in capillary electrophoresis.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2022.119782]

2. Yunong Li, Haixia Zhu, Jingbo Yang, Kehui Ke, Yanmei Zhu, Li Chen, Youyang Qu, Rui Suo, Xiujie Chen, Yulan Zhu.  (2018)  Discovering Proangiogenic Drugs in Ischemic Stroke Based on the Relationship between Protein Domain and Drug Substructure.  ACS Chemical Neuroscience,      [PMID:30346717] [10.1021/acschemneuro.8b00381]