Azithromycin (CP-62993) - Moligand™, 10mM in DMSO , Bacterial 70S ribosome inhibitor, CAS No.83905-01-5, Bacterial 70S ribosome inhibitor

CAS: 83905-01-5 Cat. No.: A409086 分子式: C₃₈H₇₂N₂O₁₂ 分子量: 748.98 EC番号: 617-500-5

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

XZ-450 | (2R,​3S,​4R,​5R,​8R,​10R,​11R,​12S,​13S,​14R)​-13-​[(2,​6-​dideoxy-​3-​C-​methyl-​3-​O-​methyl-​α-​L-​ribo-​hexopyranosyl)​oxy]​-​2-​ethyl-​3,​4,​10-​trihydroxy-​3,​5,​6,​8,​10,​12,​14-​heptamethyl-​11-​[[3,​4,​6-​trideoxy-​3-​(dimethylamino)​-​β

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
In vitro

Azithromycin reduces about 40% of IL-8 mRNA and protein expression in cystic fibrosis (CF) cells reaching the levels of non-CF cells. Azithromycin results in 50% and 70% reduction of NF-kappaB and AP-1 DNA binding, respectively, leading to levels of non-CF cells. Azithromycin significantly enhances the intensity of a co-stimulatory molecule, CD80, on DCs but not CD86 and CD40 in dendritic cells (DCs). Azithromycin significantly increases the production of IL-10 and Clarithromycin (CAM) significantly inhibits the production of IL-6 by DCs. Azithromycin increases IL-10 and CAM decreases IL-2 productions significantly, when naive T cells derived from spleen are co-cultured with DCs treated in advance with LPS and these macrolides. Azithromycin selectively inhibits fluid-phase endocytosis of horseradish peroxidase and lucifer yellow in J774 mouse macrophages. Azithromycin delays sequestration of receptor-bound transferrin and peroxidase-anti-peroxidase immune complexes into cell-surface endocytic pits and vesicles. Azithromycin down-regulates cell surface transferrin receptors, but not Fc gamma receptors, by causing a major delay in the accessibility of internalized transferrin receptors to the recycling route, without slowing down subsequent efflux, resulting in redistribution of the surface pool to an intracellular pool. Azithromycin inserts into the DOPC lipid bilayer, so as to decrease its cohesion and to facilitate the merging of DPPC into the DOPC fluid matrix.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:

Specifications

同義語

XZ-450 | (2R,​3S,​4R,​5R,​8R,​10R,​11R,​12S,​13S,​14R)​-13-​[(2,​6-​dideoxy-​3-​C-​methyl-​3-​O-​methyl-​α-​L-​ribo-​hexopyranosyl)​oxy]​-​2-​ethyl-​3,​4,​10-​trihydroxy-​3,​5,​6,​8,​10,​12,​14-​heptamethyl-​11-​[[3,​4,​6-​trideoxy-​3-​(dimethylamino)​-​β

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

AGONIST, INHIBITOR

作用メカニズム

Bacterial 70S ribosome inhibitor

製品の性質

ALogP

4

名前と識別子

異性体SMILES

CC[C@@H]1[C@@]([C@@H]([C@H](N(C[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O

WGKドイツ

2

RTECS

RN6960000

分子量

748.98

Reaxy-Rn

5387583

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5387583&ln=

関連ターゲット（人間）

MLNR Tchem Motilin receptor (1 Activities)

Discover Target: MLNR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 25 mg/mL (198.23 mM)