B-Raf IN 10 - ≥99% , CAS No.1425485-87-5

CAS: 1425485-87-5 Cat. No.: B647848 分子式: C₂₂H₂₁F₃N₄O₄S 分子量: 494.49

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC 50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity

In Vitro

B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E. B-Raf IN 10 shows an IC 50 between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E. B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: A375, SK-MEL-28, SK-MEL-31 and CHL-1 Concentration: Incubation Time: 72 h Result: Showed inhibition with IC 50 s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.

Form:Solid

IC50& Target:BRAF-V600E < 50 nM (IC 50 ) Braf 50-100 nM (IC 50 )

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC 50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

分子量

494.49

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (202.23 mM; ultrasonic and warming and heat to 60°C)