B220 - ≥99% , CAS No.112228-65-6

CAS: 112228-65-6 Cat. No.: B651335 分子式: C₂₀H₂₂N₄ 分子量: 318.42

グレード＆純度 ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

B220 is an antiviral agent which can inhibit the growth of HSV-1 , HSV-2 and human cytomegalovirus ( CMV ).

In Vitro

B220 is an antiviral agent which can inhibit the growth of HSV-1, HSV-2 and human cytomegalovirus (CMV). B220 inhibits neutrophil release of reactive oxygen species, as well as intracellular generation of reactive oxygen species. The inhibition is not achieved through direct oxygen radical scavenger activity of B220, and B220 has no immediate effects on the activity of the assembled oxidase. The neutrophil capability to phagocytose fluorescein-labeled opsonized yeast cells is reduced by B220. Cells preincubated with B220 (10 µg/mL) and then stimulated with the formylated peptide fMLP mobilize fewer C3 receptors on their surface than the control cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Assay

Cells preincubated with or without B220 are stimulated with N-formylmethionyl-leucyl-phenylalanine (fMLP) for 5 min and then fixed in paraformaldehyde [4% w/v in phosphate-buffered saline (PBS); 30 min on melting ice]. For detection of CR3, 10 µL of conjugated mAb is added to a cell pellet (approximately 100 µL) of 10 6 cells. The mixture is incubated for 30 min on ice and then washed twice with PBS. The amount of antibody bound is examined by flow cytometry. The release of vitamin B12-binding protein is assayed after activation of the cells with fMLP for 5 min using the cyanocobalamin technique. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:HSV-1 HSV-2

仕様

仕様と純度

≥99%

生化学的・生理学的メカニズム

B220 is an antiviral agent which can inhibit the growth of HSV-1 , HSV-2 and human cytomegalovirus ( CMV ).

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

分子量

318.42