BI-2545 - ≥99% , CAS No.2162961-71-7

CAS: 2162961-71-7 Cat. No.: B649217 分子式: C₂₃H₁₉F₆N₅O₃ 分子量: 527.42

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC 50 s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively

In Vitro

BI-2545 displays good potency in the LPA and rat whole blood assay with IC 50 s of 29 nM and 96 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BI-2545 (10 mg/kg; p.o.) has high and sustained in vivo efficacy in reducing LPAs . BI-2545 (10 mg/kg; p.o.) has a half-life of t 1/2 =3.4 hours . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rat Dosage: 10 mg/kg Administration: Oral administration Result: Reduces the sum of the plasma LPA species up to 90%.

Form:Solid

IC50& Target:C50: 2.2 nM (human ATX), 3.4 nM (rat ATX)

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC 50 s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

• 分子量: 527.42

化学的性質と物理的性質

• 溶解度: DMSO : 250 mg/mL (474.01 mM; Need ultrasonic)