BI-4924 - 10mM in DMSO , CAS No.2244452-09-1

CAS: 2244452-09-1 Cat. No.: B654559 分子式: C₂₁H₂₀Cl₂N₂O₆S 分子量: 499.36

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase ( PHGDH ) inhibitor ( IC 50 =3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC 50 of 2200 nM at 72 h

In Vitro

BI-4924 is a highly potent co-factor nicotinamide adenine dinucleotide (NADH/NAD + )-competitive PHGDH inhibitor. BI-4924 shows high selectivity against the majority of other dehydrogenase targets. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:PHGDH

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase ( PHGDH ) inhibitor ( IC 50 =3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis wi

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

• 分子量: 499.36