The antiarrhythmic effects of Bidisomide, a new class I antiarrhythmic drug is investigated in early-phase ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats. Bidisomide (5 mg/kg) reduces the number of premature ventricular complexes and the incidence of ventricular tachycardia and ventricular fibrillation similarly to Mexiletine (MXT) and Disopyramide (DSP) in rats with ventricular arrhythmias induced by coronary artery occlusion. In rats with ventricular arrhythmias induced by coronary artery reperfusion following a 5 min coronary occlusion, the antiarrhythmic effects of 5 mg/kg of Bidisomide are similar to those of the same doses of MXT and DSP. All three drugs significantly slow the heart rate . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

仕様

同義語

仕様と純度

≥99%

生化学的・生理学的メカニズム

Bidisomide (SC40230) is a class I antiarrhythmic agent.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

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純度

≥99%

名前と識別子

カノニカル・スマイル

CC(C)N(CCC(CCN1CCCCC1)(C2=CC=CC=C2Cl)C(=O)N)C(=O)C

IUPAC Name

2-[2-[acetyl(propan-2-yl)amino]ethyl]-2-(2-chlorophenyl)-4-piperidin-1-ylbutanamide

InChIKey

GTEPPJFJSNSNIH-UHFFFAOYSA-N

INCHI

1S/C22H34ClN3O2/c1-17(2)26(18(3)27)16-12-22(21(24)28,19-9-5-6-10-20(19)23)11-15-25-13-7-4-8-14-25/h5-6,9-10,17H,4,7-8,11-16H2,1-3H3,(H2,24,28)

異性体SMILES

CC(C)N(CCC(CCN1CCCCC1)(C2=CC=CC=C2Cl)C(=O)N)C(=O)C

代替CAS番号

116078-65-0

PubChem CID

59798

MeSH用語

alpha-(2-(acetyl(1-methylethyl)amino)ethyl)-alpha-(2-chlorophenyl)-1-piperidinebutanamide;bidisomide;bidisomide, (+)-isomer;bidisomide, (+-)-isomer;bidisomide, (-)-isomer;SC 40230;SC-40230

分子量

407.98

ドキュメント

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詳細データ

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - 分類 Benzene and substituted derivatives
    - Subclass Phenylacetamides

Kingdom	Organic compounds
Superclass	Benzenoids
分類	Benzene and substituted derivatives
Subclass	Phenylacetamides
Intermediate Tree Nodes	Not available
Direct Parent	Phenylacetamides
Alternative Parents	Aralkylamines Chlorobenzenes Piperidines Aryl chlorides Fatty amides Tertiary carboxylic acid amides Acetamides Trialkylamines Primary carboxylic acid amides Amino acids and derivatives Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives Organic oxides Organochlorides Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Phenylacetamide - Chlorobenzene - Halobenzene - Aralkylamine - Aryl chloride - Aryl halide - Fatty amide - Piperidine - Fatty acyl - Tertiary carboxylic acid amide - Acetamide - Tertiary aliphatic amine - Tertiary amine - Primary carboxylic acid amide - Amino acid or derivatives - Carboxamide group - Organoheterocyclic compound - Azacycle - Carboxylic acid derivative - Hydrocarbon derivative - Organohalogen compound - Organic oxygen compound - Organic nitrogen compound - Organochloride - Organonitrogen compound - Carbonyl group - Organic oxide - Organooxygen compound - Amine - Organopnictogen compound - Aromatic heteromonocyclic compound
説明	This compound belongs to the class of organic compounds known as phenylacetamides. These are amide derivatives of phenylacetic acids.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3 D構造

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レビュー

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溶解度	DMSO : 250 mg/mL (612.78 mM; Need ultrasonic)
分子量	408.000 g/mol
XLogP3	3.100
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	9
Exact Mass	407.234 Da
Monoisotopic Mass	407.234 Da
Topological Polar Surface Area	66.600 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	522.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Bidisomide - ≥99% , CAS No.116078-65-0

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概要

仕様