Bidisomide - ≥99% , CAS No.116078-65-0

CAS: 116078-65-0 Cat. No.: B649110 分子式: C₂₂H₃₄ClN₃O₂ 分子量: 407.98 PubChem CID: 59798

GRADE & PURITY ≥99%

Synonyms

Bidisomide (USAN/INN) | GTEPPJFJSNSNIH-UHFFFAOYSA-N | 1-PIPERIDINEBUTANAMIDE,A-[2-[ACETYL(1-METHYLETHYL)AMINO]ETHYL]-A-(2-CHLOROPHENYL)- | alpha-[2-[acetyl (1-methylethyl)amino]ethyl]-alpha-(2-chlorophenyl)-1-piperidinebutanamide | Bidisomidum | Bidisomid

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Bidisomide (SC40230) is a class I antiarrhythmic agent.

In Vivo

The antiarrhythmic effects of Bidisomide, a new class I antiarrhythmic drug is investigated in early-phase ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats. Bidisomide (5 mg/kg) reduces the number of premature ventricular complexes and the incidence of ventricular tachycardia and ventricular fibrillation similarly to Mexiletine (MXT) and Disopyramide (DSP) in rats with ventricular arrhythmias induced by coronary artery occlusion. In rats with ventricular arrhythmias induced by coronary artery reperfusion following a 5 min coronary occlusion, the antiarrhythmic effects of 5 mg/kg of Bidisomide are similar to those of the same doses of MXT and DSP. All three drugs significantly slow the heart rate . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

同義語

Bidisomide (USAN/INN) | GTEPPJFJSNSNIH-UHFFFAOYSA-N | 1-PIPERIDINEBUTANAMIDE,A-[2-[ACETYL(1-METHYLETHYL)AMINO]ETHYL]-A-(2-CHLOROPHENYL)- | alpha-[2-[acetyl (1-methylethyl)amino]ethyl]-alpha-(2-chlorophenyl)-1-piperidinebutanamide | Bidisomidum | Bidisomid

仕様と純度

≥99%

生化学的・生理学的メカニズム

Bidisomide (SC40230) is a class I antiarrhythmic agent.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥99%

名前と識別子

• カノニカル・スマイル: CC(C)N(CCC(CCN1CCCCC1)(C2=CC=CC=C2Cl)C(=O)N)C(=O)C
• IUPAC Name: 2-[2-[acetyl(propan-2-yl)amino]ethyl]-2-(2-chlorophenyl)-4-piperidin-1-ylbutanamide
• InChIKey: GTEPPJFJSNSNIH-UHFFFAOYSA-N
• INCHI: 1S/C22H34ClN3O2/c1-17(2)26(18(3)27)16-12-22(21(24)28,19-9-5-6-10-20(19)23)11-15-25-13-7-4-8-14-25/h5-6,9-10,17H,4,7-8,11-16H2,1-3H3,(H2,24,28)
• 異性体SMILES: CC(C)N(CCC(CCN1CCCCC1)(C2=CC=CC=C2Cl)C(=O)N)C(=O)C
• 代替CAS番号: 116078-65-0
• PubChem CID: 59798
• MeSH用語: alpha-(2-(acetyl(1-methylethyl)amino)ethyl)-alpha-(2-chlorophenyl)-1-piperidinebutanamide;bidisomide;bidisomide, (+)-isomer;bidisomide, (+-)-isomer;bidisomide, (-)-isomer;SC 40230;SC-40230
• 分子量: 407.98

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 分類 Benzene and substituted derivatives
      • Subclass Phenylacetamides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 分類: Benzene and substituted derivatives
• Subclass: Phenylacetamides
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylacetamides
• Alternative Parents: Aralkylamines Chlorobenzenes Piperidines Aryl chlorides Fatty amides Tertiary carboxylic acid amides Acetamides Trialkylamines Primary carboxylic acid amides Amino acids and derivatives Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives Organic oxides Organochlorides Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenylacetamide - Chlorobenzene - Halobenzene - Aralkylamine - Aryl chloride - Aryl halide - Fatty amide - Piperidine - Fatty acyl - Tertiary carboxylic acid amide - Acetamide - Tertiary aliphatic amine - Tertiary amine - Primary carboxylic acid amide - Amino acid or derivatives - Carboxamide group - Organoheterocyclic compound - Azacycle - Carboxylic acid derivative - Hydrocarbon derivative - Organohalogen compound - Organic oxygen compound - Organic nitrogen compound - Organochloride - Organonitrogen compound - Carbonyl group - Organic oxide - Organooxygen compound - Amine - Organopnictogen compound - Aromatic heteromonocyclic compound
• 説明: This compound belongs to the class of organic compounds known as phenylacetamides. These are amide derivatives of phenylacetic acids.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

Homo sapiens (32628 Activities)

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関連ターゲット（非人間）

Canis familiaris (36305 Activities)

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作用メカニズム

化学的性質と物理的性質

• 溶解度: DMSO : 250 mg/mL (612.78 mM; Need ultrasonic)
• 分子量: 408.000 g/mol
• XLogP3: 3.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 407.234 Da
• Monoisotopic Mass: 407.234 Da
• Topological Polar Surface Area: 66.600 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 522.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1