免疫抑制作用と抗腫瘍作用を有するキノリンカルボン酸誘導体。哺乳類のミトコンドリアのジヒドロオロチン酸デヒドロゲナーゼ（DHODH；IC50 = 12 nM）の活性を阻害することにより、ピリミジン合成を阻害する。哺乳類以外の動物種のDHODHには影響を与えない。接着分子のグリコシル化を阻害することも報告されている。TRAIL誘発アポトーシスに対するU1690小細胞肺がん細胞の感受性を増強し、ドキソルビシンの抗腫瘍効果を相乗的に増強する（～100μM）。
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| 分類 | Quinolines and derivatives |
| Subclass | Phenylquinolines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylquinolines |
| Alternative Parents | Quinoline carboxylic acids Phenylpyridines Biphenyls and derivatives Haloquinolines Pyridinecarboxylic acids Fluorobenzenes Methylpyridines Aryl fluorides Heteroaromatic compounds Carboxylic acid salts Azacyclic compounds Carboxylic acids Organic metal halides Organic sodium salts Organic zwitterions Organooxygen compounds Organofluorides Organic oxides Hydrocarbon derivatives Organonitrogen compounds |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Phenylquinoline - Quinoline-4-carboxylic acid - Biphenyl - 2-phenylpyridine - Haloquinoline - Pyridine carboxylic acid - Pyridine carboxylic acid or derivatives - Fluorobenzene - Halobenzene - Methylpyridine - Monocyclic benzene moiety - Benzenoid - Aryl fluoride - Aryl halide - Pyridine - Heteroaromatic compound - Carboxylic acid salt - Azacycle - Organic metal halide - Organic alkali metal salt - Carboxylic acid derivative - Carboxylic acid - Hydrocarbon derivative - Organofluoride - Organohalogen compound - Organic zwitterion - Organonitrogen compound - Organic sodium salt - Organooxygen compound - Organic nitrogen compound - Organic salt - Organic oxygen compound - Organic oxide - Aromatic heteropolycyclic compound |
| 説明 | This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | 日付 | 商品 |
|---|---|---|---|
 I2406240 | Certificate of Analysis | Sep 14, 2024 | B684682 |
| 溶解度 | Solvent:water, Max Conc. mg/mL: 39.73, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 39.73, Max Conc. mM: 100 |
|---|---|
| 分子量 | 397.300 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 3 |
| Exact Mass | 397.089 Da |
| Monoisotopic Mass | 397.089 Da |
| Topological Polar Surface Area | 53.000 Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 557.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
