Broflanilide - ≥99% , CAS No.1207727-04-5

CAS: 1207727-04-5 Cat. No.: B647090 Molecular Weight: 663.28 EC Number: 690-677-4 PubChem CID: 53341374

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor , and inhibits S. litura RDL GABAR, with an IC 50 value of 1.3 nM.

In Vitro

Broflanilide is an insecticide and metabolized to desmethyl-broflanilide, which is a potent and selective antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC 50 value of 1.3 nM. Desmethyl-broflanilide shows weak activity against human GABA A α1β2γ2 receptor, the mammalian GABA A α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC 50 s of >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G (IC 50 s, 0.706, 0.149 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor , and inhibits S. litura RDL GABAR, with an IC 50 value of 1.3 nM.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Purity

≥99%

Names and Identifiers

• Isomeric SMILES: CN(C1=CC=CC(=C1F)C(=O)NC2=C(C=C(C=C2Br)C(C(F)(F)F)(C(F)(F)F)F)C(F)(F)F)C(=O)C3=CC=CC=C3
• PubChem CID: 53341374
• Molecular Weight: 663.28

Chemical and Physical Properties

• Solubility: DMSO : 250 mg/mL (376.91 mM; Need ultrasonic)
• Molecular Weight: 663.300 g/mol
• XLogP3: 7.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 5
• Exact Mass: 662.006 Da
• Monoisotopic Mass: 662.006 Da
• Topological Polar Surface Area: 49.400 Ų
• Heavy Atom Count: 41
• Formal Charge: 0
• Complexity: 922.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Yifan Li, Shujun Ni, Yunping Wang, Ruichi Li, Hong Sun, Xuan Ye, Zhen Tian, Yalin Zhang, Jiyuan Liu.  (2023)  The chemosensory protein 1 contributes to indoxacarb resistance in Plutella xylostella (L.).  PEST MANAGEMENT SCIENCE,      [PMID:36809665] [10.1002/ps.7415]