Broussonin E - 10mM in DMSO , CAS No.90902-21-9

CAS: 90902-21-9 Cat. No.: B655298 分子式: C₁₇H₂₀O₄ 分子量: 288.34 PubChem CID: 14213544

グレード＆純度 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis

In Vitro

Broussonin E (20 μM, 3 h) inhibits the LPS ( Lipopolysaccharides , HY-D1056)-stimulated phosphorylation of ERK and p38 MAPK. Broussonin E can activate janus kinase (JAK) 2, signal transducer and activator of transcription (STAT) 3. Broussonin E (0-20 μM, 3 h) can suppress the LPS-induced pro-inflammatory production in RAW264.7 cells, involving TNF-α, IL-1β, IL-6, COX-2 and iNOS. Broussonin E enhances the expressions of anti-inflammatory mediators such as IL-10, CD206 and arginase-1 (Arg-1) in LPS-stimulated RAW264.7 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: RAW264.7 cells Concentration: 2.5, 5, 10 and 20 Incubation Time: 3 h Result: Inhibited p-ERK and p-p38 MAPK, but not p-JNK MAPK expression in LPS-stimulated RAW264.7 cells.

IC50& Target:ERK p38 MAPK JAK2 STAT3 IL-1β IL-6 COX-2 IL-10

仕様

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

名前と識別子

異性体SMILES

COC1=CC(=C(C=C1)CCCC2=CC(=C(C=C2)OC)O)O

PubChem CID

14213544

分子量

288.34