BSc3094 - ≥98% , CAS No.946857-84-7

CAS: 946857-84-7 Cat. No.: B650707 分子式: C₁₇H₁₂N₆O₃S 分子量: 380.38

グレード＆純度 ≥98%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

BSc3094 is a Tau aggregation inhibitor. BSc3094 can be used for the research of Alzheimer's disease (AD)

In Vivo

BSc3094 (3 mg/kg; i.v.) direct intraventricular administration reduces sarkosyl-insoluble Tau . BSc3094 (0.075~1.5 mM; intraventricular administration) reduces the levels of sarkosyl-insoluble Tau in cortical extracts by ≈70% . BSc3094 reverses the pre-synaptic impairment in organotypic hippocampal slices from pro-aggregant mice, by reversing the pairedpulse depression observed in non-treated pro-aggregant Tau slices after applying a paired-pulse stimulus of the Schaffer collaterals. BSc3094 reverses the increase in Tau phosphorylation levels in rTg4510 mice down to control level. BSc3094 partially reversed the memory deficits in rTg4510 mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice Dosage: 3 mg/kg Administration: I.v. Result: Direct intraventricular administration reduced sarkosyl-insoluble Tau. Animal Model: rTg4510 mice Dosage: 0.075~1.5 mM Administration: Intraventricular administration Result: Reduced the levels of sarkosyl-insoluble Tau in cortical extracts by ≈70%.

Form:Solid

IC50& Target:Tau aggregation

仕様

仕様と純度

≥98%

生化学的・生理学的メカニズム

BSc3094 is a Tau aggregation inhibitor. BSc3094 can be used for the research of Alzheimer's disease (AD).

保管条件

Protected from light,Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

名前と識別子

カノニカル・スマイル

O=C(C1=CC=C2N=CNC2=C1)NNC3=NC(C4=CC=C([N+]([O-])=O)C=C4)=CS3

分子量

380.38

化学的性質と物理的性質

• 溶解度: DMSO : 33.33 mg/mL (87.62 mM; Need ultrasonic)