Name: BSJ-4-116 - ≥98% , CAS No.2519823-34-6
SKU: B414496
Availability: InStock

BSJ-4-116 - ≥98% , CAS No.2519823-34-6

CAS: 2519823-34-6 Cat. No.: B414496 分子式: C₄₀H₄₉ClN₈O₈S 分子量: 837.38 PubChem CID: 155235839

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BSJ-4-116 - ≥98% CAS No(2519823-34-6) by Aladdin Scientific

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注文可能

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要 Specifications 名前と識別子 Documentation Advanced Data 3 D構造関連ターゲット（人間）関連ターゲット（非人間）作用メカニズム証明書（CoA、COO、BSE/TSEと分析図）化学的性質と物理的性質ソリューション計算機レビュー

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

Information

BSJ-4-116 BSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12) . BSJ-4-116 exhibits potent antiproliferative effects.

Targets

CDK12

In vitro

BSJ-4-116 selectively degrads CDK12 as assessed through quantitative proteomics. BSJ-4-116 downregulates the expression of DDR genes and exhibits antiproliferative activity in cancer cells. BSJ-4-116 also substantially suppresses the phosphorylation of Pol II Ser2 and Thr4.

Cell Research(from reference)

Cell lines：Jurkat cells

Concentrations：50\u2009nM

Incubation Time：8\u2009h

Specifications

仕様と純度

≥98%

生化学的・生理学的メカニズム

BSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12). BSJ-4-116 exhibits potent antiproliferative effects.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

名前と識別子

パブケム・シド	504773679
パブケム・シド・ウル	https://pubchem.ncbi.nlm.nih.gov/substance/504773679
カノニカル・スマイル	CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3CCCN(C3)CCCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O
IUPAC Name	N-[7-[(3R)-3-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]piperidin-1-yl]heptyl]-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide
InChIKey	YJOJMGTVKMABKQ-FIQOPJFZSA-N
INCHI	1S/C40H49ClN8O8S/c1-25(2)58(55,56)32-16-7-6-14-29(32)45-36-28(41)22-43-40(47-36)44-26-12-11-21-48(23-26)20-9-5-3-4-8-19-42-34(51)24-57-31-15-10-13-27-35(31)39(54)49(38(27)53)30-17-18-33(50)46-37(30)52/h6-7,10,13-16,22,25-26,30H,3-5,8-9,11-12,17-21,23-24H2,1-2H3,(H,42,51)(H,46,50,52)(H2,43,44,45,47)/t26-,30?/m1/s1
異性体SMILES	CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)N[C@@H]3CCCN(C3)CCCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O
PubChem CID	155235839
分子量	837.38

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

3 D構造

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レビュー

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Lot Number	Certificate Type	日付	商品
L2210361	Certificate of Analysis	Sep 17, 2025	B414496
L2210377	Certificate of Analysis	Sep 17, 2025	B414496
L2210385	Certificate of Analysis	Sep 17, 2025	B414496

溶解度	Solubility (25°C) In vitro DMSO: 100 mg/mL (119.42 mM); Water: Insoluble; Ethanol: Insoluble;
分子量	837.400 g/mol
XLogP3	5.400
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	13
Rotatable Bond Count	18
Exact Mass	836.308 Da
Monoisotopic Mass	836.308 Da
Topological Polar Surface Area	217.000 Å²
Heavy Atom Count	58
Formal Charge	0
Complexity	1570.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1