BV-6 TFA salt - Moligand™, ≥98% , CAS No.1001600-56-1(freebase)

CAS: 1001600-56-1(freebase) Cat. No.: B413788 分子式: C₇₀H₉₆N₁₀O₈.xCF₃COOH 分子量: 1205.57（free）

GRADE & PURITY Moligand™, ≥98%

Synonyms

N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide):trifluoroacetic acid(1:x)

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Information

BV-6 is a SMAC mimetic, dualcIAPandXIAPinhibitor.

Targets

cIAP ; XIAP

In vitro

BV6 inhibits the cell viability of HCC193 NSCLC cells with IC50 of 7.2 μM, induces apoptosis in both HCC193 and H460 cell lines, and also significantly enhances the radiosensitivity of these cell lines through activation of cleaved caspase-8 and cleaved caspase-9, respectively. In immature dendritic cells, BV-6 treatment results in moderate activation of the classical NF-kB pathway. Furthermore, BV-6 increases CIK cell-mediated lysis of hematological (H9, THP-1, and Tanoue) and solid malignancies (RH1, RH30, and TE671). BV-6 also enhances apoptosis of peripheral blood mononuclear cells and most notably has an inhibitory effect on immune cells limiting their cytotoxic potential.

Cell Research(from reference)

Cell lines：HCC193 and H460 cells 

Concentrations：~30 μM 

Incubation Time：~48 hours 

Specifications

同義語

N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide):trifluoroacetic acid(1:x)

仕様と純度

Moligand™, ≥98%

生化学的・生理学的メカニズム

BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

純度

≥98%

名前と識別子

パブケム・シド

488200364

パブケム・シド・ウル

https://pubchem.ncbi.nlm.nih.gov/substance/488200364

カノニカル・スマイル

CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC(C(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NCCCCCCNC(=O)C(NC(=O)C5CCCN5C(=O)C(NC(=O)C(C)NC)C6CCCCC6)C(C7=CC=CC=C7)C8=CC=CC=C8

分子量

1205.57（free）

関連ターゲット（人間）

XIAP Tchem E3 ubiquitin-protein ligase XIAP (1 Activities)

Discover Target: XIAP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 100 mg/mL (82.94 mM); Water: 100 mg/mL (82.94 mM); Ethanol: 100 mg/mL warmed with 50ºC Water: bath (82.94 mM)