C3N-Dbn-Trp2 is an inhibitor for ATP-binding cassette transporter ABCB1. C3N-Dbn-Trp2 inhibits the ABCB1-mediated Rhodamine 123 efflux in cells HEK293T and HCT-15 with IC 50 of 5.9 µM and 2.2 µM. C3N-Dbn-Trp2 inhibits the Doxorubicin efflux, enhances the cytotoxicity of Doxorubicin in ABCB1-expressing cells.
その他の情報
| CAS | 2631659-57-7 |
|---|---|
| 保管条件 | Store at -20°C |
| 入荷 | Ice chest + Ice pads |
| Product Description | C3N-Dbn-Trp2 is an inhibitor for ATP-binding cassette transporter ABCB1. C3N-Dbn-Trp2 inhibits the ABCB1-mediated Rhodamine 123 efflux in cells HEK293T and HCT-15 with IC 50 of 5.9 µM and 2.2 µM. C3N-Dbn-Trp2 inhibits the Doxorubicin efflux, enhances the cytotoxicity of Doxorubicin in ABCB1-expressing cells. |
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