Camonsertib - Moligand™, ≥98% , Inhibitor of ATR serine/threonine kinase, CAS No.2417489-10-0, Inhibitor of ATR serine/threonine kinase

CAS: 2417489-10-0 Cat. No.: C608306 分子式: C₂₁H₂₆N₆O₃ 分子量: 410.47

GRADE & PURITY Moligand™, ≥98%

Synonyms

Camonsertib | NSC841442 | NSC-841442 | ATR inhibitor 4;Camonsertib | 8-Oxabicyclo[3.2.1]octan-3-ol, 3-[6-[(3R)-3-methyl-4-morpholinyl]-1-(1H-pyrazol-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-, (3-endo)- | Rp 3500 | S1Z7Y5G56T | camonsertib [INN]

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Camonsertib (RP-3500) is a selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. Camonsertib shows 30-fold selectivity for ATR over mTOR (IC50=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. Camonsertib has potent antitumor activity.

Specifications

同義語

Camonsertib | NSC841442 | NSC-841442 | ATR inhibitor 4;Camonsertib | 8-Oxabicyclo[3.2.1]octan-3-ol, 3-[6-[(3R)-3-methyl-4-morpholinyl]-1-(1H-pyrazol-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-, (3-endo)- | Rp 3500 | S1Z7Y5G56T | camonsertib [INN]

仕様と純度

Moligand™, ≥98%

保管条件

Protected from light,Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Inhibitor of ATR serine/threonine kinase

純度

≥98%

名前と識別子

• パブケム・シド: 528763866
• カノニカル・スマイル: C[C@@H]1COCCN1C2=NC3=C(C=NN3C4=CC=NN4)C(=C2)C5(C[C@H]6CC[C@@H](C5)O6)O
• 異性体SMILES: C[C@@H]1COCCN1C2=NC3=C(C=NN3C4=CC=NN4)C(=C2)C5(C[C@H]6CC[C@@H](C5)O6)O
• 分子量: 410.47

関連ターゲット（人間）

ATR Tchem Serine/threonine-protein kinase ATR (0 Activities)

Discover Target: ATR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 感度: light & Moisture sensitive
• 分子量: 410.500 g/mol
• XLogP3: 1.600
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 410.207 Da
• Monoisotopic Mass: 410.207 Da
• Topological Polar Surface Area: 101.000 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 628.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1