CCG 50014 - Moligand™, 10mM in DMSO , Inhibitor of regulator of G-protein signaling 19;Inhibitor of regulator of G-protein signaling 4;Inhibitor of regulator of G-protein signaling 8, CAS No.883050-24-6, Inhibitor of regulator of G-protein signaling 19;Inhibitor of regulator of G-protein signaling 4;Inhibitor of regulator of G-protein signaling 8

CAS: 883050-24-6 Cat. No.: C408506 分子式: C₁₆H₁₃FN₂O₂S 分子量: 316.35

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1,2,4-Thiadiazolidine-3,5-dione, 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

CCG 50014 CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.
In vitro

CCG-50014 is highly potent at inhibiting RGS4 and it fully inhibits several other RGS proteins, including RGS8, -16, and -19, but does not have activity on RGS7. Furthermore, CCG-50014 has no activity on a mutated form of RGS4 that lacks cysteine residues in the RGS homology domain (RGS4Cys−). CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG-50014 is able to inhibit the RGS4−Gαo protein−protein interaction in a living cell. CCG-50014 represents the first of a class of small molecule RGS inhibitors that function in a cellular environment. ^{[1] [2]}

In vivo

Cell Data

cell lines：human granulosa cell lines (GC1a, HGL5, COV434)

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

同義語

1,2,4-Thiadiazolidine-3,5-dione, 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Inhibitor of regulator of G-protein signaling 19;Inhibitor of regulator of G-protein signaling 4;Inhibitor of regulator of G-protein signaling 8

名前と識別子

異性体SMILES

CC1=CC=C(C=C1)N2C(=O)N(C(=O)S2)CC3=CC=C(C=C3)F

WGKドイツ

3

分子量

316.35

Reaxy-Rn

22320416

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22320416&ln=

関連ターゲット（人間）

RGS19 Tchem Regulator of G-protein signaling 19 (1 Activities)

Discover Target: RGS19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RGS8 Tchem Regulator of G-protein signaling 8 (1 Activities)

Discover Target: RGS8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 (3 Activities)

Discover Target: RGS4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)