CCG273441 - ≥98% , CAS No.2750414-35-6

CAS: 2750414-35-6 Cat. No.: C647402 分子式: C₂₆H₂₄ClFN₄O₃ 分子量: 494.95

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

CCG273441 is a covalent inhibitor of G protein-coupled receptor ( GPCR ) kinase 5 ( GRK5 ) with an IC 50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC 50 =4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent handle

In Vitro

Human GRKs (GRK1−GRK7) are classified into three subfamilies: GRK1 (GRK1 and GRK7), GRK2 (GRK2 and GRK3), and GRK4 (GRK4, GRK5, and GRK6). CCG273441 (compound 9j) shows moderate potency (GRK5 IC 50 =3.8 nM) but 1000-fold selectivity over GRK2 (IC 50 =4.8 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 3.8 nM (human GRK5), 19 nM (GRK5-C474S), 4.8 μM (bovine GRK2)

Specifications

仕様と純度

≥98%

生化学的・生理学的メカニズム

CCG273441 is a covalent inhibitor of G protein-coupled receptor ( GPCR ) kinase 5 ( GRK5 ) with an IC 50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC 50 =4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent h

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

• 分子量: 494.95

化学的性質と物理的性質

• 溶解度: DMSO : 50 mg/mL (101.02 mM; Need ultrasonic)