≥99% ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。
Store at -20°C Ice chest + Ice pads に出荷。正確な仕様については、ロット固有の COA をご確認ください。
SDS、COA、データシート、仕様書をダウンロードできます。ロット固有の COA はロット番号検索で入手可能です。
クロマトグラフィー、有機合成、クロスカップリング反応に関する 0 件の査読済み論文で引用されています。
CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC 50 of 2.6 nM for human CD73 . CD73-IN-4 is potential for the research of cancer immunology
In Vitro
CD73-IN-4 (compound 4a) exhibits excellent potency against soluble hCD73 (IC 50 = 0.86 nM) and soluble mouse CD73 (mCD73; IC 50 = 3.0 nM), CHO cells overexpressing hCD73 (IC 50 = 2.6 nM) or mCD73 (IC 50 = 13 nM), and the human ovary cancer cell line SKOV-3 (IC 50 = 0.55 nM). It exhibits excellent selectivity (IC 50 > 10 000 nM) against CD39, A2aR, and NTPDase2, 3, and 8. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:CD73
危険性、取扱い、保管、および規制遵守を網羅した包括的な文書。
<<<<<<< HEAD SDS をダウンロード → ======= SDS をダウンロード → >>>>>>> release248-p3Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Nucleosides, nucleotides, and analogues |
| 分類 | Pyrazolo[3,4-d]pyrimidine glycosides |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Pyrazolo[3,4-d]pyrimidine glycosides |
| Alternative Parents | Glycosylamines Pentoses Pyrazolo[3,4-d]pyrimidines Secondary alkylarylamines Aminopyrimidines and derivatives 2-halopyrimidines Imidolactams Aryl chlorides Tetrahydrofurans Pyrazoles Organic phosphonic acids Heteroaromatic compounds Secondary alcohols 1,2-diols Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organophosphorus compounds Organochlorides Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Pyrazolo[3,4-d]pyrimidine glycoside - N-glycosyl compound - Glycosyl compound - Pentose monosaccharide - Pyrazolo[3,4-d]pyrimidine - Pyrazolopyrimidine - 2-halopyrimidine - Secondary aliphatic/aromatic amine - Halopyrimidine - Aminopyrimidine - Imidolactam - Pyrimidine - Monosaccharide - Aryl halide - Aryl chloride - Heteroaromatic compound - Tetrahydrofuran - Pyrazole - Organophosphonic acid derivative - Organophosphonic acid - Azole - Secondary alcohol - 1,2-diol - Oxacycle - Azacycle - Organoheterocyclic compound - Secondary amine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Amine - Alcohol - Aromatic heteropolycyclic compound |
| 説明 | This compound belongs to the class of organic compounds known as pyrazolo[3,4-d]pyrimidine glycosides. These are nucleosides or derivatives thereof that consist of a pyazolo[3,2-d]pyrimidine ring system that is N-glycosidically linked to a ribose or deoxyribose. They bear the sugar moiety on the pyrimidine part of the molecule. |
| External Descriptors | Not available |
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| 溶解度 | DMSO : 125 mg/mL (269.51 mM; Need ultrasonic) |
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