Cefoperazone - Moligand™, 10mM in DMSO , CAS No.62893-19-0

CAS: 62893-19-0 Cat. No.: C408712 分子式: C₂₅H₂₇N₉O₈S₂ 分子量: 645.67 EC番号: 263-749-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(6R,​7R)​-7-​[[(2R)​-​2-​[[(4-​ethyl-​2,​3-​dioxo-​1-​piperazinyl)​carbonyl]​amino]​-​2-​(4-​hydroxyphenyl)​acetyl]​amino]​-​3-​[[(1-​methyl-​1H-​tetrazol-​5-​yl)​thio]​methyl]​-​8-​oxo-5-​thia-​1-​azabicyclo[4.2.0]​oct-​2-​ene-​2-​carboxylic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Cefoperazone Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [ 3 H]E 2 17βG uptake with IC50 of 199 μM.
In vitro

In vivo

After intravenous administration of 2 g of Cefoperazone, levels in serum rang from 202μg/mL to 375 μg/mL depending on the period of drug administration. After intramuscular injection of 2 g of Cefoperazone, the mean peak serum level is 111 μg/mL at 1.5 hours. At 12 hours after dosing, mean serum levels are still 2 to 4 μg/mL. Cefoperazone is 90% bound to serum proteins.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

同義語

(6R,​7R)​-7-​[[(2R)​-​2-​[[(4-​ethyl-​2,​3-​dioxo-​1-​piperazinyl)​carbonyl]​amino]​-​2-​(4-​hydroxyphenyl)​acetyl]​amino]​-​3-​[[(1-​methyl-​1H-​tetrazol-​5-​yl)​thio]​methyl]​-​8-​oxo-5-​thia-​1-​azabicyclo[4.2.0]​oct-​2-​ene-​2-​carboxylic acid

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [³H]E₂17βG uptake with IC50 of 199 μM.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

名前と識別子

• 異性体SMILES: CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=C(C=C2)O)C(=O)N[C@H]3[C@@H]4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)O
• 分子量: 645.67
• Reaxy-Rn: 603333
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=603333&ln=

関連ターゲット（人間）

SLC22A6 Tclin Solute carrier family 22 member 6 (1 Activities)

Discover Target: SLC22A6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 100 mg/mL (138.93 mM)
• 融点（°C）: 173 °C(dec.)

参考文献

1. Yexuan Mao, Yichao Fan, Ran Yang, Youyi Wang, Qingyue Li, Meng Dang, Xianqing Huang, Lianjun Song, Pingan Zhang, Miao Song, Liang Liu, Linli Wang, Shun Yu, Qiuyan Zhao, Xiya Zhang.  (2023)  A highly sensitive electrochemical sensor derived from peptide amphiphilic inspired self-assembled, ordered gold nanoparticles for determination of 22 β-lactams.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2023.142669]

2. Shuangmin Wu, Wei Shen, Yushuang Chen, Yongli Zhu, Ren Hou, Menghong Dai, Dapeng Peng.  (2022)  Rapid Determination of Cephalexin in Animal-Derived Food by an Indirect Competitive Enzyme-Linked Immunosorbent Assay.  ANALYTICAL LETTERS,      [PMID:] [10.1080/00032719.2022.2072857]

3. Menghan Qin, Yumiao Shi, Dingkun Lu, Jingjing Deng, Guoyue Shi, Tianshu Zhou.  (2022)  High-performance Hf/Ti-doped defective Zr-MOFs for cefoperazone adsorption: Behavior and mechanisms.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2022.153494]

4. Cheng Lin, Jiarun Mao, Yihui Chen, Chunyan Hou, Xiaoqiang Qiao, Ningkun Wu, Tingting Wang.  (2025)  A halloysite nanotubes-based hybrid fluorous monolith as the mixed-mode sorbent for hydrophilic and hydrophobic interactions and its application for analysis of antibiotics from milk powder and milk samples.  FOOD CHEMISTRY,      [PMID:39986074] [10.1016/j.foodchem.2025.143440]

5. Pingping Yuan, Shijie Zhou, Qianqian Li, Lin Li, Shaoqi Qu.  (2025)  Extracellular vesicles enhance the efficacy of ceftiofur against intracellular bacterial infections.  Synthetic and Systems Biotechnology,      [PMID:40727487] [10.1016/j.synbio.2025.07.001]