CEP-37440 - 10mM in DMSO , CAS No.C661725(DMSO)

CAS: C661725(DMSO) Cat. No.: C661725

グレード＆純度 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

CEP-37440 is a potent, orally active dual FAK/ALK inhibitor with IC 50 values of 2.3 nM and 3.5 nM for FAK and ALK, respectively. CEP-37440 decreases the cell proliferation by blocking the autophosphorylation kinase activity of FAK1 (Tyr 397).

IC50& Target:IC 50 :2.3 nM (FAK) and 3.5 nM (ALK)

In Vitro:CEP-37440 (0-3000 nM; 0-192 h) decreases the proliferation of inflammatory breast cancer (IBC) cells in a dose-dependent manner. ?\nCEP-37440 (1000 nM; 0-120 h) decreases phospho-FAK1 (Tyr 397) and maintains its low level over time in FC-IBC02, SUM 1

Biological Activity:CEP-37440 is a potent, orally active dual FAK/ALK inhibitor with IC 50 values of 2.3 nM and 3.5 nM for FAK and ALK, respectively. CEP-37440 decreases the cell proliferation by blocking the autophosphorylation kinase activity of FAK1 (Tyr 397).

仕様

仕様と純度

10mM in DMSO

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

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