CH7233163 - ≥98% , CAS No.C414469

CAS: C414469 Cat. No.: C414469 分子式: C₃₁H₃₄F₃N₉O₃S 分子量: 669.72

GRADE & PURITY ≥98%

Synonyms

N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-5-isopropyl-7-(4-methylpiperazin-1-yl)-9-(2,2,2-trifluoroethoxy)-5H-pyrido[4,3-b]indol-3-amine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Information

CH7233163 is a non-covalent ATP competitive inhibitor ofEGFR-tyrosine kinasewith antitumor activities against tumor with EGFR-Del19/T790M/C797S.

Targets

EGFR

In vitro

CH7233163 shows potent antitumor activities against tumor with EGFR-Del19/T790M/C797S in vitro. CH7233163 potently inhibits the proliferation of Del19/T790M/C797S_NIH3T3 cells with IC50 of 20 nmol/L. CH7233163 potently and dose-dependently blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 can inhibit Del19/T790M/C797S signaling.

In vivo

Pharmacodynamic study is performed using Del19/T790M/C797S_NIH3T3 xenografted tumors in mice. CH7233163 clearly inhibits EGFR phosphorylation after oral administration and potent tumor regression is observed. CH7233163 has potent therapeutic efficacy against tumors with EGFR-Del19/T790M/C797S in vivo.

Cell Research(from reference)

Cell lines：NIH3T3 cells (ATCC) 

Concentrations：8 nM, 40 nM, 200 nM, 1000 nM 

Incubation Time：0.5 h-24 h, 4-7 days 

Specifications

同義語

N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-5-isopropyl-7-(4-methylpiperazin-1-yl)-9-(2,2,2-trifluoroethoxy)-5H-pyrido[4,3-b]indol-3-amine

仕様と純度

≥98%

生化学的・生理学的メカニズム

CH7233163 is a non-covalent ATP competitive inhibitor of EGFR-tyrosine kinase with antitumor activities against tumor with EGFR-Del19/T790M/C797S.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

• 分子量: 669.72

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 100 mg/mL (149.31 mM); Water: Insoluble; Ethanol: Insoluble