Chrysamine G - Moligand™, ≥95% , CAS No.6472-91-9

CAS: 6472-91-9 Cat. No.: C276464 分子式: C₂₆H₁₆N₄Na₂O₆ 分子量: 526.41 PubChem CID: 135475357

GRADE & PURITY Moligand™, ≥95%

Synonyms

Benzoic acid, 3,3'-((1,1'-biphenyl)-4,4'-diylbis(azo))bis(6-hydroxy-, disodium salt | Chrysamine | DTXSID801023495 | 3,3'-((1,1'-Biphenyl)-4,4'-diylbis(azo))bis(6-hydroxybenzoic acid), disodium salt | direct yellow 1 | disodium;2-carboxy-4-[[4-[4-[(3-carb

Storage

Protected from light,Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

概要

Chrysamine G, a carboxylic acid analogue of Congo Red, can be used as a probe of amyloid deposition in Alzheimer's disease. Chrysamine G also can inhibit Aβ-induced toxicity in PC12 cells.

Specifications

同義語

Benzoic acid, 3,3'-((1,1'-biphenyl)-4,4'-diylbis(azo))bis(6-hydroxy-, disodium salt | Chrysamine | DTXSID801023495 | 3,3'-((1,1'-Biphenyl)-4,4'-diylbis(azo))bis(6-hydroxybenzoic acid), disodium salt | direct yellow 1 | disodium;2-carboxy-4-[[4-[4-[(3-carb

仕様と純度

Moligand™, ≥95%

生化学的・生理学的メカニズム

Chrysamine G can penetrate the blood-brain barrier. It is useful in quantifying cerebral amyloid β (Aβ) deposition in Alzheimer′s disease (AD) pathological studies. New probe for β-amyloid aggregates.

保管条件

Protected from light,Store at -20°C,Argon charged,Desiccated

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

注

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

純度

≥95%

名前と識別子

• カノニカル・スマイル: C1=CC(=CC=C1C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)[O-])C(=O)O)N=NC4=CC(=C(C=C4)[O-])C(=O)O.[Na+].[Na+]
• IUPAC Name: disodium;2-carboxy-4-[[4-[4-[(3-carboxy-4-oxidophenyl)diazenyl]phenyl]phenyl]diazenyl]phenolate
• InChIKey: AZOPGDOIOXKJRA-UHFFFAOYSA-L
• INCHI: 1S/C26H18N4O6.2Na/c31-23-11-9-19(13-21(23)25(33)34)29-27-17-5-1-15(2-6-17)16-3-7-18(8-4-16)28-30-20-10-12-24(32)22(14-20)26(35)36;;/h1-14,31-32H,(H,33,34)(H,35,36);;/q;2*+1/p-2
• 異性体SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)[O-])C(=O)O)N=NC4=CC(=C(C=C4)[O-])C(=O)O.[Na+].[Na+]
• WGKドイツ: 3
• PubChem CID: 135475357
• 分子量: 526.41

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 分類 Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 分類: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzidines
• Alternative Parents: Azobenzenes Salicylic acids Benzoic acids Benzoyl derivatives 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Carboxylic acid salts Azo compounds Propargyl-type 1,3-dipolar organic compounds Carboxylic acids Organooxygen compounds Organic zwitterions Organic sodium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Azobenzene - Benzidine - Hydroxybenzoic acid - Salicylic acid or derivatives - Salicylic acid - Benzoic acid or derivatives - Benzoic acid - Benzoyl - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Vinylogous acid - Carboxylic acid salt - Azo compound - Organic 1,3-dipolar compound - Organic alkali metal salt - Carboxylic acid derivative - Propargyl-type 1,3-dipolar organic compound - Carboxylic acid - Organonitrogen compound - Organic zwitterion - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organic sodium salt - Organic nitrogen compound - Organic salt - Aromatic homomonocyclic compound
• 説明: This compound belongs to the class of organic compounds known as benzidines. These are organic compounds containing the benzidine skeleton, made up of a biphenyl ring system substituted at the 4- and 4'-positions with a unsubstituted amine group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

作用メカニズム

化学的性質と物理的性質

• 溶解度: Soluble in DMSO
• 分子量: 526.400 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 7
• Exact Mass: 526.087 Da
• Monoisotopic Mass: 526.087 Da
• Topological Polar Surface Area: 170.000 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 740.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

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