CiliobrevinA - ≥98% , CAS No.302803-72-1

CAS: 302803-72-1 Cat. No.: C133786 分子式: C17H9Cl2N3O2 分子量: 358.18 EC番号: 687-330-4 PubChem CID: 135535957
注文可能
GRADE & PURITY ≥98%
Synonyms
AKOS030243148 | BS-16448 | J-017853 | Hedgehog Pathway Inhibitor 4 | HPI-4 | (2E)-3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-1H-quinazolin-2-ylidene)propanenitrile | A16349 | A924807 | CCG-268130 | SR-01000429796 | HPI-4,Hedgehog Pathway Inhibitor 4 | SCHEMBL1
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
Size
USA
ドイツ (EU)*
Price
Qty
1mg
C133786-1mg
3 在庫あり
—

$12.90

$19.90
保存 $7.00 (35.18%)
5mg
C133786-5mg
3 在庫あり
—

$23.90

$35.90
保存 $12.00 (33.43%)
25mg
C133786-25mg
2 在庫あり
—

$51.90

$77.90
保存 $26.00 (33.38%)
100mg
C133786-100mg
2 在庫あり
—

$147.90

$221.90
保存 $74.00 (33.35%)
Enter a quantity for the sizes you want to add.
🧪
Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

General description:

HPI-4 (Ciliobrevin A, Hedgehog Pathway Inhibitor 4) is a hedgehog (Hh) pathway antagonist. It blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo.

Specifications

同義語
AKOS030243148 | BS-16448 | J-017853 | Hedgehog Pathway Inhibitor 4 | HPI-4 | (2E)-3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-1H-quinazolin-2-ylidene)propanenitrile | A16349 | A924807 | CCG-268130 | SR-01000429796 | HPI-4,Hedgehog Pathway Inhibitor 4 | SCHEMBL1
仕様と純度
≥98%
生化学的・生理学的メカニズム
Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50= 7μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
保管条件
Store at -20°C
入荷
Ice chest + Ice pads
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
アクションタイプ
INHIBITOR
純度
≥98%
名前と識別子
パブケム・シド
パブケム・シド・ウル
https://pubchem.ncbi.nlm.nih.gov/substance/504773377
カノニカル・スマイル
C1=CC=C2C(=C1)C(=O)NC(=N2)C(=C(C3=C(C=C(C=C3)Cl)Cl)O)C#N
IUPAC Name
(Z)-3-(2,4-dichlorophenyl)-3-hydroxy-2-(4-oxo-3H-quinazolin-2-yl)prop-2-enenitrile
InChIKey
UEZZGQDPOFILFH-QINSGFPZSA-N
INCHI
1S/C17H9Cl2N3O2/c18-9-5-6-10(13(19)7-9)15(23)12(8-20)16-21-14-4-2-1-3-11(14)17(24)22-16/h1-7,23H,(H,21,22,24)/b15-12-
異性体SMILES
C1=CC=C2C(=C1)C(=O)NC(=N2)/C(=C(/C3=C(C=C(C=C3)Cl)Cl)\O)/C#N
WGKドイツ
3
PubChem CID
135535957
分子量
358.18

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
分類Diazanaphthalenes
SubclassBenzodiazines
Intermediate Tree Nodes Not available
Direct ParentQuinazolines
Alternative Parents Pyrimidones  Chlorobenzenes  Heteroaromatic compounds  Lactams  Nitriles  Azacyclic compounds  Organopnictogen compounds  Organooxygen compounds  Organochlorides  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Quinazoline - Pyrimidone - Halobenzene - Chlorobenzene - Benzenoid - Pyrimidine - Monocyclic benzene moiety - Heteroaromatic compound - Lactam - Azacycle - Nitrile - Carbonitrile - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Aromatic heteropolycyclic compound
説明This compound belongs to the class of organic compounds known as quinazolines. These are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring and a pyrimidine ring.
External Descriptors Not available
3 D構造
インタラクティブ化学構造モデル





作用メカニズム
証明書(CoA、COO、BSE/TSEと分析図)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate Type日付商品
H2206153Certificate of AnalysisFeb 04, 2026 C133786
H2206154Certificate of AnalysisFeb 04, 2026 C133786
H2206155Certificate of AnalysisFeb 04, 2026 C133786
H2206156Certificate of AnalysisFeb 04, 2026 C133786
化学的性質と物理的性質
溶解度Solvent:DMSO, Max Conc. mg/mL: 35.82, Max Conc. mM: 100
分子量358.200 g/mol
XLogP33.400
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass357.007 Da
Monoisotopic Mass357.007 Da
Topological Polar Surface Area85.500 Ų
Heavy Atom Count24
Formal Charge0
Complexity637.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds1
Covalently-Bonded Unit Count1
Citations of This Product
ソリューション計算機
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