CJJ300 - ≥95% , CAS No.1807631-83-9

CAS: 1807631-83-9 Cat. No.: C650892 分子式: C₃₀H₃₃N₃ 分子量: 435.60

GRADE & PURITY ≥95%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

CJJ300 is a transforming growth factor-β ( TGF-β ) inhibitor with an IC 50 of 5.3 µM. CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex

In Vitro

CJJ300 disturbs protein-protein interactions and prevents TGF-β receptor dimerization (IC 50 = 23.6 ± 5.8 µM). CJJ300 (0-80 µM, 2 h) inhibits the phosphorylation of intracellular mediators in the downstream TGF-β signaling pathways, and suppresses the expression of markers of EMT (epithelial-mesenchymal transition) without cytotoxicity. CJJ300 suppresses TGF-β induced cell migration. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Human A549 lung epithelial cells Concentration: 20, 40, and 80 µM Incubation Time: 2 h Result: Significantly attenuated the increasement of P-Smad2/Smad3, P-Erk1/2 and P-Akt induced by TGF-β. Down regulated the expression of EMT-associated proteins, including fibronectin, α-SMA and MMP-2 in a dose-dependent manner.

Form:Solid

IC50& Target:IC 50 : 5.3 µM (TGF-β1-induced luciferase)

Specifications

仕様と純度

≥95%

生化学的・生理学的メカニズム

CJJ300 is a transforming growth factor-β ( TGF-β ) inhibitor with an IC 50 of 5.3 µM. CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥95%

名前と識別子

• 分子量: 435.60