CK1-IN-1 - ≥98% , CAS No.1784751-20-7

CAS: 1784751-20-7 Cat. No.: C412338 分子式: C₂₄H₁₅F₂N₃ 分子量: 383.39

GRADE & PURITY ≥98%

Synonyms

PUN51207 | Compound 1CPyridine,4-​[2-​(1-​fluoro-​2-​naphthalenyl)​-​4-​(4-​fluorophenyl)​-​1H-​imidazol-​5-​yl]​-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Information

CK1-IN-1 CK1-IN-1 (PUN51207, Compound 1C) is an inhibitor of casein kinase 1 (CK1) with IC50 of 15 nM, 16 nM and 73 nM for CK1δ, CK1ε and p38α MAPK, respectively.

Targets

CK1δ (Cell-free assay); CK1ε (Cell-free assay); p38αMAPK (Cell-free assay) 15 nM; 16 nM; 73 nM

Specifications

同義語

PUN51207 | Compound 1CPyridine,4-​[2-​(1-​fluoro-​2-​naphthalenyl)​-​4-​(4-​fluorophenyl)​-​1H-​imidazol-​5-​yl]​-

仕様と純度

≥98%

生化学的・生理学的メカニズム

CK1-IN-1 (PUN51207, Compound 1C) is an inhibitor of casein kinase 1 (CK1) with IC50 of 15 nM, 16 nM and 73 nM for CK1δ, CK1ε and p38α MAPK, respectively.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

パブケム・シド

504772861

パブケム・シド・ウル

https://pubchem.ncbi.nlm.nih.gov/substance/504772861

カノニカル・スマイル

C1=CC=C2C(=C1)C=CC(=C2F)C3=NC(=C(N3)C4=CC=NC=C4)C5=CC=C(C=C5)F

IUPAC Name

4-[2-(1-fluoronaphthalen-2-yl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine

InChIKey

PUQAFIILJICJRR-UHFFFAOYSA-N

INCHI

1S/C24H15F2N3/c25-18-8-5-16(6-9-18)22-23(17-11-13-27-14-12-17)29-24(28-22)20-10-7-15-3-1-2-4-19(15)21(20)26/h1-14H,(H,28,29)

異性体SMILES

C1=CC=C2C(=C1)C=CC(=C2F)C3=NC(=C(N3)C4=CC=NC=C4)C5=CC=C(C=C5)F

分子量

383.39

Reaxy-Rn

28532087

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28532087&ln=

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 77 mg/mL (200.83 mM); Water: Insoluble; Ethanol: Insoluble
• 分子量: 383.400 g/mol
• XLogP3: 5.400
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 383.123 Da
• Monoisotopic Mass: 383.123 Da
• Topological Polar Surface Area: 41.600 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 532.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1