Clorsulon - 10mM in DMSO , CAS No.60200-06-8

CAS: 60200-06-8 Cat. No.: C409065 分子式: C₈H₈Cl₃N₃O₄S₂ 分子量: 380.66 EC番号: 262-100-2

GRADE & PURITY 10mM in DMSO

Synonyms

MK-401 | 4-​amino-​6-​(1,​2,​2-​trichloroethenyl)​-1,​3-​benzenedisulfonamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Clorsulon (MK-401) is used in the treatment of Fasciola hepatica infections in calves and sheep.
In vitro

Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a K_i of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro.

In vivo

Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation.
Cell Data

cell lines：NHEK, A431, MCF-7, and MDA-468

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

同義語

MK-401 | 4-​amino-​6-​(1,​2,​2-​trichloroethenyl)​-1,​3-​benzenedisulfonamide

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Clorsulon (MK-401) is used in the treatment of Fasciola hepatica infections in calves and sheep.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

• 異性体SMILES: C1=C(C(=CC(=C1N)S(=O)(=O)N)S(=O)(=O)N)C(=C(Cl)Cl)Cl
• 分子量: 380.66
• Reaxy-Rn: 2821757
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2821757&ln=

化学的性質と物理的性質

• 融点（°C）: 194-203°C