≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells
In Vitro
CM03 (0.4 μM; 24 or 48 h) increases the level of γ-H2AX protein when in combination with SAHA in MIA PaCa-2 and PANC-1. CM03 (0-100 nM; 96 h) exhibits highly anti-proliferative activity against pancreatic cancer cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MIA PaCa-2 and PANC-1 Concentration: 0.4 μM Incubation Time: 24 h for MIA PaCa-2, 48 h for PANC-1 Result: Significantly increased the level of γ-H2AX protein when in combination with SAHA (1 μM). Cell Proliferation AssayCell Line: MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 Concentration: 0-100 nM Incubation Time: 96 h Result: Exhibited highly anti-proliferative activity against pancreatic cancer cell lines with GI 50 s of 9.0 nM, 15.6 nM, 26.5 nM and 15.5 nM in MIA PaCa-2, PANC-1, Capan-1 and BxPC-3, respectively.
Form:Solid
IC50& Target:DNA synthesis
| 異性体SMILES | C1CCN(C1)CCN=C2C=C3C4=C(C=CC5=C(N(C(=O)C2=C54)CCCN6CCOCC6)O)C(=O)N(C3=O)CCCN7CCOCC7 |
|---|---|
| PubChem CID | 137203116 |
| 分子量 | 632.75 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| 溶解度 | DMSO : 2 mg/mL (3.16 mM; ultrasonic and warming and heat to 60°C) |
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