COH34 - ≥99% , CAS No.906439-72-3

CAS: 906439-72-3 Cat. No.: C648836 分子式: C₁₈H₁₅NOS 分子量: 293.38 PubChem CID: 135443632

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC 50 of 0.37 nM. COH34 binds to the catalytic domain of PARG ( K d =0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors

In Vitro

COH34 efficiently kills PARP inhibitor-resistant cancer cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 0.37 nM (PARG)

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC 50 of 0.37 nM. COH34 binds to the catalytic domain of PARG ( K d =0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥99%

名前と識別子

• カノニカル・スマイル: CC1=CC=C(C=C1)SN=CC2=C(C=CC3=CC=CC=C32)O
• IUPAC Name: 1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol
• InChIKey: SFUAIBHPGDRCFL-XDHOZWIPSA-N
• INCHI: 1S/C18H15NOS/c1-13-6-9-15(10-7-13)21-19-12-17-16-5-3-2-4-14(16)8-11-18(17)20/h2-12,20H,1H3/b19-12+
• PubChem CID: 135443632
• NSC番号: 191252
• 分子量: 293.38

化学的性質と物理的性質

• 溶解度: DMSO : 16.67 mg/mL (56.82 mM; Need ultrasonic)

よくある質問

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 906439-72-3, the molecular formula is C18H15NOS, and the molecular weight is 293.38 g/mol. InChIKey SFUAIBHPGDRCFL-XDHOZWIPSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.