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Corin - 10mM in DMSO , CAS No.1808113-09-8
注文可能
GRADE & PURITY 10mM in DMSO
Storage
Argon charged,Store at -80°C
Shipped In
Dry ice packs + Cold packs
Why this grade
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Argon charged,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
概要
Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC) , with a K i (inact) of 110 nM for LSD1 and an IC 50 of 147 nM for HDAC1 .
In Vitro
Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC 50 95 nM vs. MS-275 EC 50 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 147 nM (HDAC1), Ki(inact): 110 nM (LSD1)
Specifications
仕様と純度
10mM in DMSO
生化学的・生理学的メカニズム
Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC) , with a K i (inact) of 110 nM for LSD1 and an IC 50 of 147 nM for HDAC1 .
保管条件
Argon charged,Store at -80°C
入荷
Dry ice packs + Cold packs
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
アクションタイプ
INHIBITOR
名前と識別子
| PubChem CID | 134828251 |
|---|---|
| 分子量 | 428.53 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
証明書（CoA、COO、BSE/TSEと分析図）
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
ソリューション計算機
レビュー
顧客レビュー
よくある質問
How should this product be stored?
Store at ?80 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.
How is this product shipped?
This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1808113-09-8, the molecular formula is C26H28N4O2, and the molecular weight is 428.53 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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