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Costundide - analytical standard, ≥98% , CAS No.553-21-9

CAS: 553-21-9 Cat. No.: C115678 分子式: C15H20O2 分子量: 232.32 EC番号: 683-148-4
2 Citations COA
Costundide - analytical standard, ≥98% CAS No(553-21-9) by Aladdin Scientific
注文可能
グレード＆純度 Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. ≥98%
Synonyms
MFCD00210262 | HMS3677B19 | Costunlide | NSC106404 | Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS,6E,10E,11aR)- | AKOS015969714 | Costunolide | SCHEMBL92714 | (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
サイズ
USA
ドイツ (EU)*
価格
個数
20mg
C115678-20mg
6 在庫あり
—
$119.90
Enter a quantity for the sizes you want to add.
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SDS
Safety data
COA
Certificate
DS
データシート
SP
仕様書
概要 仕様 名前と識別子 ドキュメント 詳細データ Taxonomic Classification 3 D構造 関連ターゲット（人間） 関連ターゲット（非人間） 作用メカニズム 証明書（CoA、COO、BSE/TSEと分析図） 化学的性質と物理的性質 Citations of This Product ソリューション計算機 レビュー
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このグレードを選ぶ理由

analytical standard, ≥98% 分析用標準物質 ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。

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保管・配送

Store at -20°C Ice chest + Ice pads に出荷。正確な仕様については、ロット固有の COA をご確認ください。

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品質書類

SDS、COA、データシート、仕様書をダウンロードできます。ロット固有の COA はロット番号検索で入手可能です。

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文献的裏付け

クロマトグラフィー、有機合成、クロスカップリング反応に関する 2 件の査読済み論文で引用されています。

概要

Costunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been suggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathway
A sequiterpene lactone that inhibits telomerase

仕様

同義語
MFCD00210262 | HMS3677B19 | Costunlide | NSC106404 | Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS,6E,10E,11aR)- | AKOS015969714 | Costunolide | SCHEMBL92714 | (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8
仕様と純度
analytical standard, ≥98%
生化学的・生理学的メカニズム

Description:
IC50 Value: 6.2 - 9.8 ?g/mL(sarcoma cells viability)[3]
Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis.
in vitro: Costunolide significantly i

保管条件
Store at -20°C
入荷
Ice chest + Ice pads
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
等級
分析用標準物質
純度
≥98%
名前と識別子
パブケム・シド
528772114
カノニカル・スマイル
CC1=CCCC(=CC2C(CC1)C(=C)C(=O)O2)C
IUPAC Name
(3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one
InChIKey
HRYLQFBHBWLLLL-AHNJNIBGSA-N
INCHI
1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1
異性体SMILES
C/C/1=C\CC/C(=C/[C@@H]2[C@@H](CC1)C(=C)C(=O)O2)/C
WGKドイツ
3
RTECS
LY4270000
分子量
232.32
Reaxy-Rn
22984848
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22984848&ln=

ドキュメント

📋 安全データシート（SDS）

危険性、取扱い、保管、および規制遵守を網羅した包括的な文書。

<<<<<<< HEAD SDS をダウンロード → ======= SDS をダウンロード → >>>>>>> release248-p3

✅ 分析証明書（COA）

ロット固有の品質データ。ロット番号を入力して、正確な COA を取得してください。

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📊 データシート

製品仕様と用途のクイックリファレンス概要。

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🔬 仕様書

このグレードの完全な品質特性と合格基準。

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詳細データ

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassLipids and lipid-like molecules
分類Prenol lipids
SubclassTerpene lactones
Intermediate Tree Nodes Sesquiterpene lactones
Direct ParentGermacranolides and derivatives
Alternative Parents Germacrane sesquiterpenoids  Gamma butyrolactones  Tetrahydrofurans  Enoate esters  Oxacyclic compounds  Monocarboxylic acids and derivatives  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic heteropolycyclic compounds
Substituents Germacranolide - Germacrane sesquiterpenoid - Sesquiterpenoid - Gamma butyrolactone - Tetrahydrofuran - Enoate ester - Alpha,beta-unsaturated carboxylic ester - Lactone - Carboxylic acid ester - Oxacycle - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organoheterocyclic compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Carbonyl group - Aliphatic heteropolycyclic compound
説明This compound belongs to the class of organic compounds known as germacranolides and derivatives. These are sesquiterpene lactones with a structure based on the germacranolide skeleton, characterized by a gamma lactone fused to a 1,7-dimethylcyclodec-1-ene moiety.
External Descriptors Germacrenes
3 D構造
インタラクティブ化学構造モデル





関連ターゲット（人間）
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PA-1 (704 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NLRP3 Tchem NACHT, LRR and PYD domains-containing protein 3 (908 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
関連ターゲット（非人間）
murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase (389 Activities)
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NIH3T3 (5395 Activities)
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rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
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Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
作用メカニズム
証明書（CoA、COO、BSE/TSEと分析図）
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate Type日付商品
E2514227E2514227Certificate of AnalysisMay 08, 2025 C115678
E2514228E2514228Certificate of AnalysisMay 08, 2025 C115678
J1519044J1519044Certificate of AnalysisMar 10, 2023 C115678
化学的性質と物理的性質
溶解度Soluble in ethanol (50 mM), DMSO (47 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).,
比旋光度［α］118° (C=0.2,CHCl3)
融点（°C）106°C(lit.)
分子量232.320 g/mol
XLogP32.100
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass232.146 Da
Monoisotopic Mass232.146 Da
Topological Polar Surface Area26.300 Ų
Heavy Atom Count17
Formal Charge0
Complexity401.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds2
Covalently-Bonded Unit Count1
Citations of This Product
How to Cite Aladdin Scientific Products? Citations Search
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📚 用途別の引用文献

Cell viability2
Cytotoxicity screening2
Drug / compound screening2
Other applications1
2 件の引用文献をすべて見る →

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