Cotadutide acetate - ≥99% , CAS No.C659298

CAS: C659298 Cat. No.: C659298 分子式: C₁₆₉H₂₅₆N₄₂O₅₇ 分子量: 3788.14

グレード＆純度 ≥99%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Cotadutide (MEDI0382) acetate is a potent dual agonist of Glukagon-like peptide-1 (GLP-1) and GCGR with EC 50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate exhibits ability to facilitate both weight loss and glycaemic control, and allevia

Appearance:Solid

IC50& Target:EC50: 6.9 pM (GLP-1); 10.2 pM (GCGR)

In Vitro:Cotadutide acetate stimulates a concentration-dependent increase in cAMP accumulation in rat (INS-1 832/3) and human (EndoC-βH1) β-cell lines (EC 50 : 226 pM and 1051 pM, respectively ), as well as rat, mouse and human hepatocytes (EC 50 : 462 pM, 840 pM,

In Vivo:Cotadutide (10 nmol/kg, s.c., once) acetate suppresses food intake in DIO mice relative to vehicle‐treated controls. Cotadutide (10 or 30 nmol/kg, s.c., once daily for 14-16 weeks) acetate reduces body weight in DIO mice. Cotadutide (30 nmol/kg,

Biological Activity:Cotadutide (MEDI0382) acetate is a potent dual agonist of Glukagon-like peptide-1 (GLP-1) and GCGR with EC 50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate exhibits ability to facilitate both weight loss and glycaemic control, and allevia

仕様

仕様と純度

≥99%

保管条件

Desiccated,Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥99%

名前と識別子

分子量

3788.14

化学的性質と物理的性質

• 溶解度: DMSO : 12.5 mg/mL (3.30 mM; Need ultrasonic) H2O : 2 mg/mL (0.53 mM; Need ultrasonic)

よくある質問

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is C659298, the molecular formula is C169H256N42O57, and the molecular weight is 3788.14 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.