Coumberone - ≥99% , CAS No.878019-47-7

CAS: 878019-47-7 Cat. No.: C650463 分子式: C₂₂H₁₉NO₃ 分子量: 345.39

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Coumberone is a metabolic fluorogenic probe, and isoform-selective substrate for all AKR1C isoforms. Coumberone can be reduced by all four members of the AKR1C family to its fluorescent alcohol coumberol. Coumberone can be used for the research of AKR1C.

In Vitro

Coumberone (30 μM; 24 hours; HCT116 cells) is an AKR1C3 substrate and demonstrates maximal rates at ~10 μM.\nCoumberone (5 μM; 24 hours; COS-1 cells) can be used for the selective optical readout of each isoform, either AKR1C2 or AKR1C3.\nCoumberone (5 μM; 24 hours; IMR32 cells) enables real-time imaging of AKR1C induction.\nCoumberone (80 hours; IMR-32 cells) metabolism is indeed increased. Coumberone exhibits 10-fold greater catalytic efficiency for AKR1C3 than AKR1C2 in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only. ImmunofluorescenceCell Line: IMR32 cells Concentration: 5 μM Incubation Time: 24 hours Result: Enabled real-time imaging of AKR1C induction.

Form:Solid

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

Coumberone is a metabolic fluorogenic probe, and isoform-selective substrate for all AKR1C isoforms. Coumberone can be reduced by all four members of the AKR1C family to its fluorescent alcohol coumberol. Coumberone can be used for the research of AKR1C [

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥99%

名前と識別子

• カノニカル・スマイル: O=C1OC2=C(C(C(C3=CC=CC=C3)=O)=C1)C=C4C5=C2CCCN5CCC4
• 分子量: 345.39

化学的性質と物理的性質

• 溶解度: DMSO : 16.67 mg/mL (48.26 mM; ultrasonic and warming and heat to 70°C)