Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
このグレードを選ぶ理由
Moligand™, ≥99% Moligand™ ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。
保管・配送
Room temperature,Desiccated Normal に出荷。正確な仕様については、ロット固有の COA をご確認ください。
品質書類
SDS、COA、データシート、仕様書をダウンロードできます。ロット固有の COA はロット番号検索で入手可能です。
文献的裏付け
クロマトグラフィー、有機合成、クロスカップリング反応に関する 0 件の査読済み論文で引用されています。
概要
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
仕様
同義語
(RS)-α-Cyclopropyl-4-phosphonophenylglycine
仕様と純度
Moligand™, ≥99%
生化学的・生理学的メカニズム
Potent group II/III metabotropic glutamate receptor antagonist. Displays 20-fold selectivity for Group III over Group II. K i values are 11.5, 17.3 and 4.02 μM for mGlu receptor subtypes mGlu 6 mGlu 7a and mGlu 8a , respectively.
保管条件
Room temperature,Desiccated
入荷
Normal
等級
Moligand™
アクションタイプ
ANTAGONIST
作用メカニズム
Antagonist of mGlu 4 receptor;Antagonist of mGlu 8 receptor
注
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
純度
≥99%
名前と識別子
カノニカル・スマイル
C1CC1C(C2=CC=C(C=C2)P(=O)(O)O)(C(=O)O)N
IUPAC Name
2-amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid
InChIKey
IGODGTDUQSMDQU-UHFFFAOYSA-N
INCHI
1S/C11H14NO5P/c12-11(10(13)14,7-1-2-7)8-3-5-9(6-4-8)18(15,16)17/h3-7H,1-2,12H2,(H,13,14)(H2,15,16,17)
異性体SMILES
C1CC1C(C2=CC=C(C=C2)P(=O)(O)O)(C(=O)O)N
分子量
271.21
Reaxy-Rn
24162380
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24162380&ln=
ドキュメント
📋 安全データシート（SDS）
危険性、取扱い、保管、および規制遵守を網羅した包括的な文書。
<<<<<<< HEAD SDS をダウンロード → ======= SDS をダウンロード → >>>>>>> release248-p3詳細データ
Taxonomic Classification
Taxonomy Tree
- Kingdom Organic compounds
- Superclass Organic acids and derivatives
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| 分類 | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Amino acids and derivatives - Alpha amino acids and derivatives |
| Direct Parent | Alpha amino acids |
| Alternative Parents | Aralkylamines Benzene and substituted derivatives Organic phosphonic acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organophosphorus compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Alpha-amino acid - Aralkylamine - Monocyclic benzene moiety - Benzenoid - Organophosphonic acid - Organophosphonic acid derivative - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Organic nitrogen compound - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Primary amine - Hydrocarbon derivative - Organic oxide - Primary aliphatic amine - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Amine - Aromatic homomonocyclic compound |
| 説明 | This compound belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). |
| External Descriptors | Not available |
3 D構造
インタラクティブ化学構造モデル
関連ターゲット（人間）
GRM4 Tchem Metabotropic glutamate receptor 4 (1 Activities)
GRM8 Tchem Metabotropic glutamate receptor 8 (1 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
作用メカニズム
証明書（CoA、COO、BSE/TSEと分析図）
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
化学的性質と物理的性質
| 溶解度 | Soluble in 1 eq. NaOH to 100 mM |
|---|---|
| 分子量 | 271.210 g/mol |
| XLogP3 | -3.100 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 4 |
| Exact Mass | 271.061 Da |
| Monoisotopic Mass | 271.061 Da |
| Topological Polar Surface Area | 121.000 Ų |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Complexity | 383.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
ソリューション計算機
レビュー
顧客レビュー
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