CTX1 - 10mM in DMSO , CAS No.501935-96-2

CAS: 501935-96-2 Cat. No.: C654477 分子式: C₁₄H₁₀N₄ 分子量: 234.26 EC番号: 110-728-1 PubChem CID: 435038

グレード＆純度 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system

In Vitro

CTX1 binds directly to HdmX to prevent p53-HdmX complex formation, resulting in the rapidly induction of p53 in a DNA damage-independent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CTX1 ( (30 mg/kg; i.p.; five days a week; for 3 weeks) significantly enhances the survival of mice in AML model system . CTX1 exhibited significant anti-cancer activity alone as well as in combination with nutlin-3 . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:p53

仕様

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

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名前と識別子

異性体SMILES

C1=CC2=C(C=C1N)N=C3C=C(C=CC3=C2C#N)N

PubChem CID

435038

分子量

234.26