Cyanine5 NHS ester - ≥95% , CAS No.1263093-76-0

CAS: 1263093-76-0 Cat. No.: C276024 Molecular Weight: 667.55

GRADE & PURITY ≥95%

Synonyms

(2,5-dioxopyrrolidin-1-yl) 6-[(2E)-3,3-dimethyl-2-[(2E,4E)-5-(1,3,3-trimethylindol-1-ium-2- yl)penta-2,4-diylidene]indol-1-yl]hexanoate tetrafluoroborate | Amine-reactive red emitting fluorescent dye | Cy5 NHS ester

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.

Specifications

Synonyms

(2, 5-dioxopyrrolidin-1-yl) 6-[(2E)-3, 3-dimethyl-2-[(2E, 4E)-5-(1, 3, 3-trimethylindol-1-ium-2- yl)penta-2, 4-diylidene]indol-1-yl]hexanoate tetrafluoroborate | Amine-reactive red emitting fluorescent dye | Cy5 NHS ester

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Red emitting fluorescent dye for labeling of amino-groups in peptides, proteins, and oligonucleotides. Requires a small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reactions.

Storage

Protected from light, Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 504773687
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773687
• Canonical Smiles: [B-](F)(F)(F)F.CC1(C2=CC=CC=C2[N+](=C1C=CC=CC=C3C(C4=CC=CC=C4N3CCCCCC(=O)ON5C(=O)CCC5=O)(C)C)C)C
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 6-[(2E)-3,3-dimethyl-2-[(2E,4E)-5-(1,3,3-trimethylindol-1-ium-2-yl)penta-2,4-dienylidene]indol-1-yl]hexanoate;tetrafluoroborate
• InChIKey: LWGOCTDPEVJNTC-UHFFFAOYSA-N
• INCHI: 1S/C36H42N3O4.BF4/c1-35(2)26-16-11-13-18-28(26)37(5)30(35)20-8-6-9-21-31-36(3,4)27-17-12-14-19-29(27)38(31)25-15-7-10-22-34(42)43-39-32(40)23-24-33(39)41;2-1(3,4)5/h6,8-9,11-14,16-21H,7,10,15,22-25H2,1-5H3;/q+1;-1
• Molecular Weight: 667.55

Chemical and Physical Properties

• Solubility: Soluble in DMSO
• Sensitivity: light sensitive

References

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6. Liang Tingxizi, Dong Yuxiang, Cheng Irina, Wen Ping, Li Fengqin, Liu Feng, Wu Qing, Ren En, Liu Peifeng, Li Hongjun, Gu Zhen.  (2024)  In situ formation of biomolecular condensates as intracellular drug reservoirs for augmenting chemotherapy.  Nature Biomedical Engineering,      [PMID:39271933] [10.1038/s41551-024-01254-y]

7. Xiaojie Liang, Zhu Wang, Shuting Wang, Feixia Ruan, Yidan Zhang, Dan Shao, Xuemin Liu, Fangman Chen, Xuetao Shi.  (2024)  Magnetic mesoporous silica nanoparticles loaded with peptides for the targeted repair of cavernous nerve injury underlying erectile dysfunction.  BIOMATERIALS,      [PMID:39265373] [10.1016/j.biomaterials.2024.122811]

8. Shuaiyin Zhang, Xinran Xie, Ming Liu, Zhixin Li, Yang Ye, Liang Peng, Kexing Lyu, Xiaomei Sun, Yuan Yuan, Zhijun Zhang, Weiping Wen, Zhaoxu Tu.  (2025)  Biomimetic Ti3C2 nanosheets for synergistically overcoming chemoresistance and boosting immunotherapy via enhanced cuproptosis in cancer.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.165766]

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