Cyclotraxin B, CAS No.1203586-72-4

CAS: 1203586-72-4 Cat. No.: C288514 分子式: C₄₈H₇₃N₁₃O₁₇S₃ 分子量: 1200.36 PubChem CID: 90489002

GRADE & PURITY ≥98%

概要

Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC50  of  0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects。

Specifications

Product Name

Cyclotraxin B, CAS No.1203586-72-4

同義語

S-1203586-72-4 | Cyclotraxin B acetate | (3S,6R,11R,17S,20S,23S,26S,32S,35S)-6-amino-20-(4-aminobutyl)-3-(2-amino-2-oxoethyl)-17-(2-carboxyethyl)-23-[(1R)-1-hydroxyethyl]-26-[(4-hydroxyphenyl)methyl]-32-(2-methylsulfanylethyl)-2,5,13,16,19,22,25,28,31,34-

仕様と純度

≥98%

生化学的・生理学的メカニズム

Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50= 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic pr

シーケンス

CNPMGYTKEGC(Modifications: Disulfide bridge between 1 - 11)

アクションタイプ

INHIBITOR

CAS

1203586-72-4

分子タイプ

低分子化合物

保管と配送

保管条件

Store at -20°C,Argon charged

入荷

Ice chest + Ice pads