Cys-McMMAF - ≥99% , CAS No.1160590-05-5

CAS: 1160590-05-5 Cat. No.: C647381 分子式: C₅₂H₈₃N₇O₁₃S 分子量: 1046.32

GRADE & PURITY ≥99%

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models).

In Vivo

Cys-McMMAF (0.3 mg/kg, 3 mg/kg; i.v.; single dose) has a poor stability with short decline time in cynomolgus monkeys . Pharmacokinetic Analysis in Nude (nu/nu) Mice Model/IV Dose (mg/kg) C max (ng/mL) T max (hr) AUC 0-336 (ng·h/mL) t 1/2 (day) Non-Tumor 1 0.192 8 14.6 2.1 Tumor 1 0.146 8 28.2 6.0 Non-Tumor 10 0.951 8 58.5 3.0 Tumor 10 0.945 8 81.9/td> 2.9 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF ( HY-15579 ) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-D

保管条件

Protected from light,Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

• 分子量: 1046.32

化学的性質と物理的性質

• 溶解度: DMSO : 200 mg/mL (191.15 mM; Need ultrasonic)