D-3 - ≥99% , CAS No.1967815-98-0

CAS: 1967815-98-0 Cat. No.: D651496 分子式: C₄₈H₄₇N₄O₁₀P 分子量: 870.88

グレード＆純度 ≥99%

Storage

Protected from light,Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent.

In Vitro

D-3 prevents residual iPSC-induced teratoma formation in a mouse tumorigenicity assay. D-3 induces obvious loss of viability in 201B7 cells, with half maximal inhibitory concentration value of 192.3 ± 57.4 μM. D-3 induces an increase in the amount of activated elF2a, p38, and p44/42 MAPK, which\nare activated in response to cellular stress. D-3 also increases the number of Annexin-V and SYTOX-positive cells, indicating apoptotic and dead cells after D-3 treatment. D-3 has little influence on various non-iPSCs, including hepatocytes and neurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Six human iPSCs lines and one human ESC line (khES1). Concentration: 400 μM. Incubation Time: 1-2 h. Result: Sufficient to induce a viability loss (>99% in all iPSC lines and >95% in khES1).

Form:Solid

仕様

仕様と純度

≥99%

生化学的・生理学的メカニズム

D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent.

保管条件

Protected from light,Argon charged,Desiccated,Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

分子量

870.88