DBCO-CONH-S-S-NHS ester - ≥97%, used for Antibody-Drug Conjugates (ADCs): Functions as a cleavable linker for attaching drugs to antibodies. Bioconjugation: Enables efficient molecular assembly through amine and click chemistry reactions. Protein Labeling

CAS: 1435934-53-4 Cat. No.: D648358 分子式: C₂₈H₂₇N₃O₆S₂ 分子量: 565.66 PubChem CID: 98233194

GRADE & PURITY ≥97%

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

概要

DBCO-CONH-S-S-COONHS Ester or DBCO-CONH-S-S-NHS ester is a cleavable heterobifunctional linker commonly used in bioconjugation and click chemistry. It features a DBCO group for strain-promoted azide-alkyne cycloaddition (SPAAC) and an NHS ester for coupling to primary amines. Its disulfide bond enables controlled cleavage under reductive conditions, thereby supporting applications in targeted drug delivery and molecular assembly.

Specifications

仕様と純度

≥97%

生化学的・生理学的メカニズム

DBCO-CONH-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

申し込み

Antibody-Drug Conjugates (ADCs): Functions as a cleavable linker for attaching drugs to antibodies. Bioconjugation: Enables efficient molecular assembly through amine and click chemistry reactions. Protein Labeling: Facilitates protein labeling with vario

保管条件

Protected from light,Store at -20°C,Argon charged

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥97%

名前と識別子

カノニカル・スマイル

C1CC(=O)N(C1=O)OC(=O)CCSSCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethyldisulfanyl]propanoate

InChIKey

RPNGUSKTYYIUDE-UHFFFAOYSA-N

INCHI

1S/C28H27N3O6S2/c32-24(29-16-18-39-38-17-15-28(36)37-31-26(34)13-14-27(31)35)11-12-25(33)30-19-22-7-2-1-5-20(22)9-10-21-6-3-4-8-23(21)30/h1-8H,11-19H2,(H,29,32)

異性体SMILES

C1CC(=O)N(C1=O)OC(=O)CCSSCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42

PubChem CID

98233194

分子量

565.66

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (176.78 mM; Need ultrasonic)
• 分子量: 565.700 g/mol
• XLogP3: 1.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 12
• Exact Mass: 565.134 Da
• Monoisotopic Mass: 565.134 Da
• Topological Polar Surface Area: 164.000 Ų
• Heavy Atom Count: 39
• Formal Charge: 0
• Complexity: 992.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1