dBET23 is a highly effective and selective PROTAC BRD4 degrader with a DC 50/5h of ~ 50 nM for BRD4 BD1 protein.
In Vitro
dBET23 occupies the canonical binding sites on CRBN and BRD4 BD1 for thalidomide and JQ1, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
仕様
仕様と純度
≥99%
生化学的・生理学的メカニズム
dBET23 is a highly effective and selective PROTAC BRD4 degrader with a DC 50/5h of ~ 50 nM for BRD4 BD1 protein.
DMSO : 110 mg/mL (124.24 mM; ultrasonic and warming and heat to 60°C)
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よくある質問
What is the purity of this product?
This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?20 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1957234-83-1, the molecular formula is C43H45ClN8O9S, and the molecular weight is 885.38 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.