Name: Degrasyn (WP1130) - ≥98% , CAS No.856243-80-6
SKU: W126205
Availability: InStock

Degrasyn (WP1130) - ≥98% , CAS No.856243-80-6

CAS: 856243-80-6 Cat. No.: W126205 分子式: C₁₉H₁₈BrN₃O 分子量: 384.27 PubChem CID: 11222830

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Degrasyn (WP1130) - ≥98% CAS No(856243-80-6) by Aladdin Scientific

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注文可能

GRADE & PURITY ≥98%

Synonyms

WP1130 | WP-1130 | Degrasyn (WP1130) | SCHEMBL1317674 | SCHEMBL882501 | DTXSID50459281 | s11144 | WP1130(Degrasyn) | Z2312381828 | AMY20034 | (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide | EX-A2048 | AC-28415 | BDBM50437695 | HY-13264

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要 Specifications 名前と識別子 Documentation Advanced Data Taxonomic Classification 3 D構造関連ターゲット（人間）関連ターゲット（非人間）作用メカニズム証明書（CoA、COO、BSE/TSEと分析図）化学的性質と物理的性質ソリューション計算機レビュー

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT).
A selective deubiquitinase inhibitor and also suppresses Bcr/Abl.

Specifications

同義語

仕様と純度

≥98%

生化学的・生理学的メカニズム

WP1130 induces rapid down-regulation of Bcr/Abl without affecting Bcr or c-Abl and regulates the stability of Jak2 and c-Myc without affecting other kinases (HER1, HER2, c-kit, Fak, Erk1, Erk2, Akt, Btk, Src, and Src-related kinases) or transcription fact

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

パブケム・シド	504766179
パブケム・シド・ウル	https://pubchem.ncbi.nlm.nih.gov/substance/504766179
カノニカル・スマイル	CCCC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N
IUPAC Name	(E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylbutyl]prop-2-enamide
InChIKey	LIDOPKHSVQTSJY-VMEIHUARSA-N
INCHI	1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1
異性体SMILES	CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
PubChem CID	11222830
分子量	384.27

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - 分類 Pyridines and derivatives
    - Subclass Halopyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
分類	Pyridines and derivatives
Subclass	Halopyridines
Intermediate Tree Nodes	Not available
Direct Parent	2-halopyridines
Alternative Parents	Benzene and substituted derivatives Aryl bromides Heteroaromatic compounds Secondary carboxylic acid amides Nitriles Azacyclic compounds Organobromides Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2-halopyridine - Aryl bromide - Aryl halide - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Carboxamide group - Secondary carboxylic acid amide - Nitrile - Carbonitrile - Carboxylic acid derivative - Azacycle - Organic oxide - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Carbonyl group - Cyanide - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
説明	This compound belongs to the class of organic compounds known as 2-halopyridines. These are organic compounds containing a pyridine ring substituted at the 2-position by a halogen atom.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3 D構造

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レビュー

Bulk & Custom Packaging Need larger quantities or custom specifications? Contact our team for a tailored quote.

Lot Number	Certificate Type	日付	商品
I2205448	Certificate of Analysis	Mar 11, 2026	W126205
I2205449	Certificate of Analysis	Mar 11, 2026	W126205
I2205450	Certificate of Analysis	Mar 11, 2026	W126205
I2205451	Certificate of Analysis	Mar 11, 2026	W126205
I2205452	Certificate of Analysis	Mar 11, 2026	W126205

溶解度	Soluble in DMSO (77 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), ethanol (50 mg/ml at 25 °C), DMF (~20 mg/ml), and 1: 10 solution of DMF: PBS (pH 7.2) (~0.09 mg/ml).
分子量	384.300 g/mol
XLogP3	4.300
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	383.063 Da
Monoisotopic Mass	383.063 Da
Topological Polar Surface Area	65.800 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	490.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1