Deoxyelephantopin - ≥99% , CAS No.29307-03-7

CAS: 29307-03-7 Cat. No.: D649061 分子式: C₁₉H₂₀O₆ 分子量: 344.4

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber , has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB , MAPK , PI3K/Akt , and β-catenin signaling

In Vitro

Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC 50 s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively. Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:NF-κB

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber , has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB , MAPK , PI3K/Akt , and β-catenin signaling.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

カノニカル・スマイル

CC1=CC2C(C(CC3=CC(C1)OC3=O)OC(=O)C(=C)C)C(=C)C(=O)O2

IUPAC Name

(10-methyl-5-methylidene-6,14-dioxo-7,13-dioxatricyclo[10.2.1.04,8]pentadeca-1(15),9-dien-3-yl) 2-methylprop-2-enoate

InChIKey

JMUOPRSXUVOHFE-UHFFFAOYSA-N

INCHI

1S/C19H20O6/c1-9(2)17(20)24-15-8-12-7-13(23-19(12)22)5-10(3)6-14-16(15)11(4)18(21)25-14/h6-7,13-16H,1,4-5,8H2,2-3H3

異性体SMILES

CC1=CC2C(C(CC3=CC(C1)OC3=O)OC(=O)C(=C)C)C(=C)C(=O)O2

分子量

344.4

Reaxy-Rn

25965389

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25965389&ln=

化学的性質と物理的性質

• 溶解度: DMSO : 33.33 mg/mL (96.79 mM; Need ultrasonic)