Diazoxide - Moligand™, 10mM in DMSO , Activator of K ir6.1;Activator of K ir6.2, CAS No.364-98-7, Activator of K ir6.1;Activator of K ir6.2

CAS: 364-98-7 Cat. No.: D423637 分子式: C₈H₇ClN₂O₂S 分子量: 230.67 EC番号: 206-668-1

グレード＆純度 Moligand™, 10mM in DMSO

Synonyms

diazoxide|364-98-7|Proglycem|Hyperstat|Hypertonalum|Eudemine|Proglicem|Dizoxide|Mutabase|7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide|Diazossido|Diazoxidum|Sch 6783|Sch-6783|Diazoxido|SRG 95213|SRG-95213|C8H7ClN2O2S|Eudemine injection|2H-1,2,4-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

仕様

同義語

diazoxide | 364-98-7 | Proglycem | Hyperstat | Hypertonalum | Eudemine | Proglicem | Dizoxide | Mutabase | 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide | Diazossido | Diazoxidum | Sch 6783 | Sch-6783 | Diazoxido | SRG 95213 | SRG-95213 | C8H7ClN2O2S | Eudemine injection | 2H-1,2,4-

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Selective K IR 6.x (K ATP ) activator; antihypertensive.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

ACTIVATOR

作用メカニズム

Activator of K ir6.1;Activator of K ir6.2

名前と識別子

パブケム・シド

528769653

カノニカル・スマイル

CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl

IUPAC Name

7-chloro-3-methyl-4H-1λ6,2,4-benzothiadiazine 1,1-dioxide

InChIKey

GDLBFKVLRPITMI-UHFFFAOYSA-N

INCHI

1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)

異性体SMILES

CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl

WGKドイツ

3

RTECS

DK8185000

分子量

230.67

Reaxy-Rn

523846

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=523846&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 分類 Thiadiazines
      • Subclass Benzothiadiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 分類: Thiadiazines
• Subclass: Benzothiadiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: 1,2,4-benzothiadiazine-1,1-dioxides
• Alternative Parents: Imidolactams Benzenoids Aryl chlorides Organosulfonic acids and derivatives Azacyclic compounds Amidines Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 1,2,4-benzothiadiazine-1,1-dioxide - Aryl chloride - Aryl halide - Benzenoid - Imidolactam - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Azacycle - Amidine - Hydrocarbon derivative - Organonitrogen compound - Organochloride - Organohalogen compound - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• 説明: This compound belongs to the class of organic compounds known as 1,2,4-benzothiadiazine-1,1-dioxides. These are aromatic heterocyclic compounds containing a 1,2,4-benzothiadiazine ring system with two S=O bonds at the 1-position.
• External Descriptors: sulfone - organochlorine compound - benzothiadiazine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

KCNJ11 Tclin ATP-sensitive inward rectifier potassium channel 11 (1 Activities)

Discover Target: KCNJ11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 感度: Heat sensitive
• 融点（°C）: 332 °C
• 分子量: 230.670 g/mol
• XLogP3: 1.200
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 229.992 Da
• Monoisotopic Mass: 229.992 Da
• Topological Polar Surface Area: 66.900 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 360.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1