Diethyl malonate - 10mM in DMSO , CAS No.105-53-3

CAS: 105-53-3 Cat. No.: D420478 Molecular Weight: 160.17 Beilstein Registry Number: 774687 EC Number: 203-305-9
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GRADE & PURITY 10mM in DMSO
Synonyms
CCRIS 9480 | DIETHYL MALONATE | Ethyl methanedicarboxylate | EINECS 203-305-9 | Ethyl malonate (VAN) | Diethyl malonate, Vetec(TM) reagent grade, 98% | malonic acid-diethylester | Z104473166 | AMY37124 | Diethyl propanedioate | F1908-0063 | FT-0624843 | M
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Status
Price
Qty
1ml
D420478-1ml
2

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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 23 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
CCRIS 9480 | DIETHYL MALONATE | Ethyl methanedicarboxylate | EINECS 203-305-9 | Ethyl malonate (VAN) | Diethyl malonate, Vetec(TM) reagent grade, 98% | malonic acid-diethylester | Z104473166 | AMY37124 | Diethyl propanedioate | F1908-0063 | FT-0624843 | M
Specifications & Purity
10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers
Canonical SmilesCCOC(=O)CC(=O)OCC
IUPAC Namediethyl propanedioate
InChIKeyIYXGSMUGOJNHAZ-UHFFFAOYSA-N
INCHI1S/C7H12O4/c1-3-10-6(8)5-7(9)11-4-2/h3-5H2,1-2H3
Isomeric SMILES CCOC(=O)CC(=O)OCC
WGK Germany 1
RTECS OO0700000
Molecular Weight 160.17
Beilstein 774687
Reaxy-Rn 774687
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=774687&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
SubclassDicarboxylic acids and derivatives
Intermediate Tree Nodes Not available
Direct ParentDicarboxylic acids and derivatives
Alternative Parents 1,3-dicarbonyl compounds  Carboxylic acid esters  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAliphatic acyclic compounds
Substituents 1,3-dicarbonyl compound - Dicarboxylic acid or derivatives - Carboxylic acid ester - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(non-human)
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SensitivityMoisture sensitive.
Refractive Index1.4143
Flash Point(°F)194 °F
Flash Point(°C)93℃
Boil Point(°C)198-199°C
Melt Point(°C)-50°C
Molecular Weight160.170 g/mol
XLogP31.000
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass160.074 Da
Monoisotopic Mass160.074 Da
Topological Polar Surface Area52.600 Ų
Heavy Atom Count11
Formal Charge0
Complexity125.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Zhengrong Lin, Hongye Li, Jinpeng Zhang, Xiaomei Pei, Zhao Chen, Zhenggang Cui, Binglei Song.  (2023)  Toroidal micelles formed in viscoelastic aqueous solutions of a double-tailed surfactant with two quaternary ammonium head groups.  Soft Matter,  20  (4): (804-812).  [PMID:38168697] [10.1039/D3SM01132A]
2. Linlin Lv, Weiwei Luo, Yixiao Zhou, Tiechun Li, Quanping Diao, Pinyi Ma, Daqian Song.  (2023)  A highly sensitive ratiometric fluorescent probe based on fluorescein coumarin for detecting hydrazine in actual water and biological samples.  LUMINESCENCE,  38  (2): (159-165).  [PMID:36601685] [10.1002/bio.4435]
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10. Linlin Yang, Jun Zhao, Xinling Yu, Ruilong Zhang, Guangmei Han, Renyong Liu, Zhengjie Liu, Tingting Zhao, Ming-Yong Han, Zhongping Zhang.  (2018)  Dynamic mapping of spontaneously produced H2S in the entire cell space and in live animals using a rationally designed molecular switch.  ANALYST,  143  (8): (1881-1889).  [PMID:29560968] [10.1039/C7AN01802A]
11. Xueyi Sun, Yu Wang, Xiaofeng Zhang, Shihong Zhang, Zhao Zhang.  (2015)  A new coumarin based chromo-fluorogenic probe for selective recognition of cyanide ions in an aqueous medium.  RSC Advances,  (117): (96905-96910).  [PMID:] [10.1039/C5RA14500G]
12. Binglei Song, Zonghui Xu, Xiaona Yu, Shuyi Chen, Shunan Li, Rongzhen Shi, Zhenggang Cui.  (2015)  Synthesis and Solution Properties of a Double-Tailed Quaternary Ammonium Surfactant with a Protrudent Head Group.  JOURNAL OF SURFACTANTS AND DETERGENTS,  18  (6): (1081-1088).  [PMID:] [10.1007/s11743-015-1738-y]
13. Yue Huang, Yang Liu, Chuan Dong, Qi Zan, Feng Feng, Ruibing Wang, Shaomin Shuang.  (2025)  A Dual-Channel Fluorescent Probe with Mitochondria-Immobilization: Detecting Polarity and Viscosity During Mitophagy.  BIOSENSORS & BIOELECTRONICS,      [PMID:39954518] [10.1016/j.bios.2025.117246]
14. Jun Li, Pingcong Lv, Hongli Ou, Xianling Yang, Youyi Chang, Yanli Li, Qian Zhou, Yimin Shan, Xianggui Chen, Xiaoqi Yu.  (2025)  A novel self-ratiometric fluorescent sensor of sodium alginate hydrogel bead doping with coumarin derivative with extremely acidic pH visual monitoring of fruit juice freshness.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40089227] [10.1016/j.ijbiomac.2025.142099]
15. Wenhui Lu, Chunli Ding, Mingshuo Zhu.  (2024)  Discrimination of coal geographical origins through HS-GC-IMS assisted with machine learning algorithms in larceny case.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:39232421] [10.1016/j.chroma.2024.465330]
16. Haohong Liu, Keyan Zheng, Qingwen Fang, Yunlian Shi, Ziyin Xie, Jie Wang, Xuliang Nie, Xugen Shi, Ruqiang Cui, Gang Sun, Dayong Peng.  (2025)  Synthesis of new pyrido[1,2-α] pyrimidinone derivatives and investigation of their insecticidal activity.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2025.141712]
17. Zhengrong Lin, Zutian Bi, Hongye Li, Xiaomei Pei, Zhao Chen, Zhenggang Cui, Binglei Song.  (2024)  Wormlike Micellar Glycerol Solutions Formed from a Double-Tailed Surfactant with Two Quaternary Ammonium Head Groups.  LANGMUIR,      [PMID:39254156] [10.1021/acs.langmuir.4c02024]
18. Xingtian Zhang, Boyuan Yang, Yong Zhang, Xiaoyu Du, Liwei Hou, Tao Zhou, Hongtao Chu, Wenhui Ma.  (2025)  A Cell-Compatible Polyethylene Glycol Sensor for Dual-Mode Cu2+ Tracking: In Vivo Biosensing and Smartphone-Based High-Sensitivity Detection In Vitro.  JOURNAL OF APPLIED POLYMER SCIENCE,      [PMID:] [10.1002/app.57592]
19. Jiahua Lu, Chunmu Wang, Yusen Wu, Jie Zhu, Jujun Ruan.  (2025)  Recycling of waste crystalline silicon photovoltaic modules: Efficient decapsulation and silver extraction using environmental-friendly reagents and deep eutectic solvents.  SOLAR ENERGY MATERIALS AND SOLAR CELLS,      [PMID:] [10.1016/j.solmat.2025.113882]
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