Diethyl-pythiDC - 10mM in DMSO , CAS No.1821370-70-0

CAS: 1821370-70-0 Cat. No.: D655151 分子式: C₁₄H₁₄N₂O₄S 分子量: 306.34

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Diethyl-pythiDC is an inhibitor of collagen prolyl 4-hydroxylases (CP4Hs).

In Vitro

Diethyl-pythiDC inhibits CP4H activity in cultured cells at concentrations that do not cause iron deficiency. MDA-MB-231 cells are treated with biheteroaryl dicarboxylates, and assayed for cytotoxicity and indicators of iron deficiency. None of the esterified biheteroaryl dicarboxylates exhibited cytotoxic activity at high micromolar concentrations. Cells treated with dihydroxybenzoate (EDHB demonstrate a strong iron-deficient phenotype. In contrast, cells treated with Diethyl-pythiDC (Diethyl pythiDC) appear to be normal at concentrations as high as 500 μM. Treatment with Diethyl-pythiDC and low levels of diethyl pyimDC does not affect the level of TfR, HIF-1α, or ferritin. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:CP4H

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Diethyl-pythiDC is an inhibitor of collagen prolyl 4-hydroxylases (CP4Hs).

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

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名前と識別子

• 分子量: 306.34