Diphemanil Methylsulfate - 10mM in DMSO , Muscarinic acetylcholine receptor M1 antagonist, CAS No.62-97-5, Muscarinic acetylcholine receptor M1 antagonist

CAS: 62-97-5 Cat. No.: D409097 分子式: C₂₁H₂₇NO₄OS 分子量: 405.51 EC番号: 200-552-4

グレード＆純度 10mM in DMSO

Synonyms

Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).
In vitro

Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. In addition to its well known antimuscarinic effects, Diphemanil Methylsulfate also possesses direct smooth musclespasmolytic activity.

In vivo

The pharmacokinetic experiments show that absorption of diphemanil methylsulphate is slow (tmax = 2 to 4 h), the mean half-life is 8.35 h, and the amount of the drug recovered in urine within 48 h ranges from 0.6 to 7.4% of the administered dose. Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

仕様

同義語

Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate (1:1)

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ANTAGONIST

作用メカニズム

Muscarinic acetylcholine receptor M1 antagonist

名前と識別子

異性体SMILES

C[N+]1(CCC(=C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C.COS(=O)(=O)[O-]

RTECS

TN5075000

分子量

405.51

Reaxy-Rn

3842254

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3842254&ln=

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 34 mg/mL (113.92 mM); Ethanol: 28 mg/mL (93.81 mM); Water: Insoluble
• 融点（°C）: 194 °C