Divalproex Sodium - 10mM in DMSO , Succinate semialdehyde dehydrogenase inhibitor, CAS No.76584-70-8, Succinate semialdehyde dehydrogenase inhibitor

CAS: 76584-70-8 Cat. No.: D408831 分子式: C₁₆H₃₂NaO₄ 分子量: 311.42 EC番号: 630-325-9

GRADE & PURITY 10mM in DMSO

Synonyms

2-​propyl-pentanoic acid, sodium salt (2:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Divalproex Sodium Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.
In vitro

Divalproex sodium enhances IM-induced cell growth inhibition, apoptosis and cell cycle arrest in K562-S and K562-G cells. Divalproex sodium enhances the inhibitory effects of IM on SIRT1 expression in K562-S and K562-G cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1. Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas a lower dose of Divalproex, 50 mg/kg, has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

同義語

2-​propyl-pentanoic acid, sodium salt (2:1)

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

作用メカニズム

Succinate semialdehyde dehydrogenase inhibitor

名前と識別子

• 異性体SMILES: CCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+]
• 分子量: 311.42
• Reaxy-Rn: 8462424
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8462424&ln=

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro Water: 100 mg/mL (46.3 mM)