DKFZ-748 - ≥98% , CAS No.2490709-68-5

CAS: 2490709-68-5 Cat. No.: D649897 分子式: C₁₈H₂₃N₃O₃ 分子量: 329.39

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

DKFZ-748 is a selective HDAC10 inhibitor ( pIC 50 =7.66), and shows anti-tumor activity.

In Vitro

DKFZ-748 shows dose-dependent growth inhibition of HeLa cells in a polyamine-limiting in vitro tumor model. DKFZ-748 (1-100 μM; 72 h) induces HDAC acetylation of BE(2)-C cells. DKFZ 748 shows significant accumulation of N8 acetyl- and N1,8-diacetylspermidine in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: BE(2)-C cells Concentration: 1, 10, 100 μM Incubation Time: 72 h Result: Induced significant HDAC acetylation only at the highest tested concentration (100 μM).

Form:Solid

Specifications

仕様と純度

≥98%

生化学的・生理学的メカニズム

DKFZ-748 is a selective HDAC10 inhibitor ( pIC 50 =7.66), and shows anti-tumor activity.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

• 分子量: 329.39