Docebenone - 10mM in DMSO , CAS No.80809-81-0

CAS: 80809-81-0 Cat. No.: D655736 分子式: C₂₁H₂₆O₃ 分子量: 326.43 EC番号: 635-956-3 PubChem CID: 1967

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.

In Vitro

Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB 4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production. Docebenone at 10-200 μM increases [Ca 2+ ] i concentration dependently. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Docebenone might protect experimental acute necrotizing pancreatitis in rats. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10 -8 -10 -5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10 -8 -10 -5 M. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:5-LO

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

名前と識別子

異性体SMILES

CC1=C(C(=O)C(=C(C1=O)C)CCCCC#CCCCC#CCO)C

代替CAS番号

80809-81-0

PubChem CID

1967

MeSH用語

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone;AA 861;AA-861;AA861

分子量

326.43