Dot1L-IN-1 TFA - ≥98% , CAS No.D658712

CAS: D658712 Cat. No.: D658712 Molecular Weight: 760.23

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Dot1L-IN-1 TFA is a highly potent and selective Dot1L inhibitor with a K i of 2 pM and an IC 50 of <0.1 nM. Dot1L-IN-1 TFA potently suppresses H3K79 dimethylation (IC 50 =3 nM), as well as the activity of the HoxA9 promoter (IC 50 =17 nM) in HeLa and Molm

Appearance:Solid

IC50& Target:DOT1L

In Vitro:Dot1L-IN-1 (analogue 7) TFA effectively inhibits proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC 50 =5 nM). MCE has not independently confirmed the accuracy of these methods. They are for

Biological Activity:Dot1L-IN-1 TFA is a highly potent and selective Dot1L inhibitor with a K i of 2 pM and an IC 50 of <0.1 nM. Dot1L-IN-1 TFA potently suppresses H3K79 dimethylation (IC 50 =3 nM), as well as the activity of the HoxA9 promoter (IC 50 =17 nM) in HeLa and Molm

Specifications

Specifications & Purity

≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Molecular Weight: 760.23

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (65.77 mM; Need ultrasonic)